S
Sermin Genc
Researcher at Dokuz Eylül University
Publications - 101
Citations - 4977
Sermin Genc is an academic researcher from Dokuz Eylül University. The author has contributed to research in topics: Erythropoietin & Neuroprotection. The author has an hindex of 34, co-authored 92 publications receiving 4133 citations. Previous affiliations of Sermin Genc include Academy of Sciences of the Czech Republic & Health Science University.
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Journal ArticleDOI
Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.
Murat Celik,Necati Gokmen,Serhat Erbayraktar,Mustafa Akhisaroglu,Selman KonakC,Cagnur Ulukus,Sermin Genc,Kursad Genc,Emel Sagiroglu,Anthony Cerami,Michael Brines +10 more
TL;DR: Clinical trials evaluating rHu-EPO's potential to prevent motor neuron apoptosis and the neurological deficits that occur as a consequence of ischemic injury are warranted.
Journal ArticleDOI
The adverse effects of air pollution on the nervous system.
TL;DR: Emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology.
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A Practical Guide to Immunoassay Method Validation
Ulf Andreasson,Armand Perret-Liaudet,Linda J C van Waalwijk van Doorn,Kaj Blennow,Davide Chiasserini,Sebastiaan Engelborghs,Tormod Fladby,Sermin Genc,Niels Kruse,H. Bea Kuiperij,Luka Kulic,Piotr Lewczuk,Brit Mollenhauer,Barbara Mroczko,Lucilla Parnetti,Eugeen Vanmechelen,Marcel M. Verbeek,Bengt Winblad,Henrik Zetterberg,Henrik Zetterberg,Marleen J.A. Koel-Simmelink,Charlotte E. Teunissen +21 more
TL;DR: Standard operating procedures (SOPs) with step-by-step instructions for a number of different validation parameters is included in the present work together with a validation report template, which allow for a well-ordered presentation of the results.
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Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
Burak Ibrahim Arioz,Bora Tastan,Emre Tarakcioglu,Kemal Ugur Tufekci,Melis Olcum,Nevin Ersoy,Alper Bagriyanik,Kursad Genc,Sermin Genc +8 more
TL;DR: Melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition ofNLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1 β (IL-1β) maturation and secretion.
Journal ArticleDOI
Erythropoietin and the nervous system
TL;DR: The current knowledge on the neurotrophic and neuroprotective properties of Epo, the mechanisms by which Epo produces neuroprotection and the signal transduction systems regulated by Epo in the nervous system are summarized.