The adverse effects of air pollution on the nervous system.
TLDR
Emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology.Abstract:
Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air pollution on the pulmonary and cardiovascular systems have been well established in a series of major epidemiological and observational studies. In the recent past, air pollution has also been associated with diseases of the central nervous system (CNS), including stroke, Alzheimer's disease, Parkinson's disease, and neurodevelopmental disorders. It has been demonstrated that various components of air pollution, such as nanosized particles, can easily translocate to the CNS where they can activate innate immune responses. Furthermore, systemic inflammation arising from the pulmonary or cardiovascular system can affect CNS health. Despite intense studies on the health effects of ambient air pollution, the underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology. A better understanding of the mediators and mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system and mental health.read more
Citations
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Environmental and Health Impacts of Air Pollution: A Review.
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Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study.
Anna Oudin,Bertil Forsberg,Annelie Nordin Adolfsson,Nina Lind,Lars Modig,Maria Nordin,Steven Nordin,Rolf Adolfsson,Lars-Göran Nilsson +8 more
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TL;DR: Results from controlled clinical and animal studies using ultrafine elemental carbon particles permit some preliminary conclusions: The authors should be more cautious about introducing technologies based on the assumption that they result in cleaner air with fewer and less toxic contaminants.
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Neurotoxicity of traffic-related air pollution
TL;DR: Exposure to air pollution, and to traffic‐related air pollution or DE in particular, may lead to neurotoxicity, and air pollution is emerging as a possible etiological factor in neurodevelopmental and neurodegenerative disorders.
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