Long Yan

TL;DR: This study provides the first data causally linking increased stromal collagen to mammary tumor formation and metastasis, and demonstrates that fundamental differences arise and persist in epithelial tumor cells that progressed within collagen-dense microenvironments.

TL;DR: A novel method for deriving functional maps of intracellular reduction-oxidation ratio in vivo via measurement of the fluorescence lifetimes and the ratio of free and protein-bound NADH using two-photon fluorescence lifetime imaging (FLIM).

TL;DR: It is found that σ1R activation prevents methamphetamine-induced, DAT-mediated increases in firing activity of dopamine neurons, and support the ρ1R as a putative target for the treatment of methamphetamine addiction.

TL;DR: Application of multiphoton excitation, SHG, and fluorescence lifetime imaging microscopy to relevant issues regarding the tumor-stromal interaction, cellular metabolism, and cell signaling in breast cancer is described.

TL;DR: This work demonstrates the utility of multimodal MPE/SHG/FLIM for imaging both exogenous and/or endogenous fluorophores in mammary tumors or relevant 3-D systems and presents a method for imaging and differentiating signals from multiple fluoride that can have overlapping spectra via SLIM Plotter-a computational tool for visualizing and analyzing large spectral-lifetime data sets.