P
Paolo P. Provenzano
Researcher at University of Minnesota
Publications - 76
Citations - 11182
Paolo P. Provenzano is an academic researcher from University of Minnesota. The author has contributed to research in topics: Extracellular matrix & Cancer. The author has an hindex of 32, co-authored 69 publications receiving 9490 citations. Previous affiliations of Paolo P. Provenzano include Fred Hutchinson Cancer Research Center & University of Washington.
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Journal ArticleDOI
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.
Paolo P. Provenzano,Carlos Cuevas,Amy Chang,Vikas K. Goel,Daniel D. Von Hoff,Sunil R. Hingorani,Sunil R. Hingorani +6 more
TL;DR: It is shown that systemic administration of an enzymatic agent can ablate stromal HA from autochthonous murine PDA, normalize IFP, and re-expand the microvasculature and in combination with the standard chemotherapeutic, gemcitabine, the treatment permanently remodels the tumor microenvironment and consistently achieves objective tumor responses, resulting in a near doubling of overall survival.
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Collagen reorganization at the tumor-stromal interface facilitates local invasion
Paolo P. Provenzano,Kevin W. Eliceiri,Jay M. Campbell,David R. Inman,John G. White,Patricia J. Keely +5 more
TL;DR: Three tumor-associated collagen signatures (TACS) are observed and defined that provide novel markers to locate and characterize tumors and should provide indications that a tumor is, or could become, invasive, and may serve as part of a strategy to help identify and characterize breast tumors in animal and human tissues.
Journal ArticleDOI
Collagen density promotes mammary tumor initiation and progression
Paolo P. Provenzano,David R. Inman,Kevin W. Eliceiri,Justin G Knittel,Long Yan,Curtis Rueden,John G. White,Patricia J. Keely +7 more
TL;DR: This study provides the first data causally linking increased stromal collagen to mammary tumor formation and metastasis, and demonstrates that fundamental differences arise and persist in epithelial tumor cells that progressed within collagen-dense microenvironments.
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Aligned collagen is a prognostic signature for survival in human breast carcinoma.
Matthew W. Conklin,Jens C. Eickhoff,Kristin M. Riching,Carolyn Pehlke,Kevin W. Eliceiri,Paolo P. Provenzano,Andreas Friedl,Patricia J. Keely +7 more
TL;DR: It is proposed that quantifying collagen alignment is a viable, novel paradigm for the prediction of human breast cancer survival because of the strong statistical evidence for poor survival in patients with TACS and because the assessment can be performed in routine histopathological samples imaged via second harmonic generation or using picrosirius.
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Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage
TL;DR: The current data provide compelling evidence for the importance of the mechanical features of the microenvironment, and suggest that mechanotransduction in these cells occurs through a FAK–Rho–ERK signaling network with extracellular signal-regulated kinase (ERK) as a bottleneck through which much of the response to mechanical stimuli is regulated.