Patricia J. Keely

TL;DR: Three tumor-associated collagen signatures (TACS) are observed and defined that provide novel markers to locate and characterize tumors and should provide indications that a tumor is, or could become, invasive, and may serve as part of a strategy to help identify and characterize breast tumors in animal and human tissues.

TL;DR: This study provides the first data causally linking increased stromal collagen to mammary tumor formation and metastasis, and demonstrates that fundamental differences arise and persist in epithelial tumor cells that progressed within collagen-dense microenvironments.

TL;DR: It is proposed that quantifying collagen alignment is a viable, novel paradigm for the prediction of human breast cancer survival because of the strong statistical evidence for poor survival in patients with TACS and because the assessment can be performed in routine histopathological samples imaged via second harmonic generation or using picrosirius.

TL;DR: This work considers here how cells use focal adhesions to regulate signaling complexes and integrin function, and examines how this regulation controls complex cellular behaviors in response to matrices of diverse physical and biochemical properties.

TL;DR: It is shown that caveolin-1 (Cav1) favors cell elongation in three-dimensional cultures and promotes Rho- and force-dependent contraction, matrix alignment, and microenvironment stiffening through regulation of p190RhoGAP.