M
Mehmet S. Inan
Researcher at Beth Israel Deaconess Medical Center
Publications - 11
Citations - 924
Mehmet S. Inan is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Gene expression & Monocyte. The author has an hindex of 9, co-authored 11 publications receiving 851 citations. Previous affiliations of Mehmet S. Inan include Yeditepe University & King Abdulaziz City for Science and Technology.
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Journal ArticleDOI
Gene Signatures of Progression and Metastasis in Renal Cell Cancer
Jon Jones,Hasan H. Otu,Dimitrios Spentzos,Shakirahmed Kolia,Mehmet S. Inan,Wolf D. Beecken,Christian Fellbaum,Xuesong Gu,Marie Joseph,Allan J. Pantuck,Dietger Jonas,Towia A. Libermann +11 more
TL;DR: The gene expression of primary tumors provides us information about the metastatic status in the respective patients and has the potential, if prospectively validated, to enrich the armamentarium of diagnostic tests in RCC.
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Gene Expression Profile Classification: A Review
TL;DR: This review attempted to present a unified approach that considers both class-prediction and class-discovery, and discussed important issues such as preprocessing of gene expression data, curse of dimensionality, feature extraction/selection, and measuring or estimating classifier performance.
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Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Dilek Colak,Asmaa Nofal,Albandary Al-Bakheet,Maimoona S. Nirmal,Hatim A. Jeprel,Abdelmoneim Eldali,Taher Al-Tweigeri,Asma Tulbah,Dahish Ajarim,Osama Al Malik,Mehmet S. Inan,Namik Kaya,Ben Ho Park,Suad M. Bin Amer +13 more
TL;DR: This study provides the first comprehensive genomic analysis of breast cancer in Middle Eastern women in age-specific cohorts and potential markers for cancer progression in young women, and demonstrates that cancer appearing in youngWomen contain distinct biological characteristics and deregulated signaling pathways.
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Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.
Franck Grall,Xuesong Gu,Lujian Tan,Je-Yoel Cho,Mehmet S. Inan,Allison R. Pettit,Usanee Thamrongsak,Bob K. Choy,Cathy Manning,Yasmin Akbarali,Luiz F. Zerbini,Susan A. Rudders,Steven R. Goldring,Ellen M. Gravallese,Peter Oettgen,Mary B. Goldring,Towia A. Libermann +16 more
TL;DR: ESE-1 is expressed insynovial tissues in RA and, to a variable extent, in OA, and is specifically induced in synovial fibroblasts, chondrocytes, osteoblasts, and monocyte/macrophages by IL-1beta, TNFalpha, or LPS.
Journal ArticleDOI
The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes
Franck Grall,Wolf Christian Prall,Wanjiang Wei,Xuesong Gu,Je-Yoel Cho,Bob K. Choy,Luiz F. Zerbini,Mehmet S. Inan,Steven R. Goldring,Ellen M. Gravallese,Mary B. Goldring,Peter Oettgen,Towia A. Libermann +12 more
TL;DR: It is reported that the induction of COX‐2 expression by lipopolysaccharide and pro‐inflammatory cytokines correlates with ESE‐1 induction in monocyte/macrophages and is established as an important player in the regulation of inflammation.