M
Michael Bayewitch
Researcher at Weizmann Institute of Science
Publications - 22
Citations - 4703
Michael Bayewitch is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Adenylyl cyclase & Cannabinoid receptor. The author has an hindex of 18, co-authored 22 publications receiving 4474 citations. Previous affiliations of Michael Bayewitch include National Institutes of Health & Wolfson Medical Center.
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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
Raphael Mechoulam,Shimon Ben-Shabat,Lumir Hanus,Moshe Ligumsky,Norbert E. Kaminski,Anthony R. Schatz,Asher Gopher,Shlomo Almog,Billy R. Martin,David R. Compton,Roger G. Pertwee,Graeme Griffin,Michael Bayewitch,Jacob Barg,Zvi Vogel +14 more
TL;DR: Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature.
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The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling
TL;DR: It is shown, using a CB2 transfected Chinese hamster ovary cell line, that this receptor binds a variety of tricyclic cannabinoid ligands as well as the endogenous ligand anandamide, which characterize the CB2 receptor as a functional and distinctive member of the cannabinoid receptor family.
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Opiate-induced Adenylyl Cyclase Superactivation Is Isozyme-specific
TL;DR: The results suggest that the phenomena of tolerance and withdrawal involve specific adenylyl cyclase isozymes, and it is demonstrated that the superactivation is isozyme-specific.
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Anandamide may mediate sleep induction
Raphael Mechoulam,Ester Fride,Lumir Hanu,Tzviel Sheskin,Tiziana Bisogno,Vincenzo Di Marzo,Michael Bayewitch,Zvi Vogel +7 more
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Adenylylcyclase Supersensitization in μ-Opioid Receptor-transfected Chinese Hamster Ovary Cells Following Chronic Opioid Treatment
TL;DR: Both the overshoot and acute opioid-induced cyclase inhibition are blocked by naloxone and are pertussis toxin-sensitive, indicating that both phenomena are mediated by the μ-receptor and Gi/Go proteins.