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Shimon Ben-Shabat
Researcher at Ben-Gurion University of the Negev
Publications - 77
Citations - 6797
Shimon Ben-Shabat is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Prodrug & Targeted drug delivery. The author has an hindex of 27, co-authored 69 publications receiving 6060 citations. Previous affiliations of Shimon Ben-Shabat include Columbia University & Hebrew University of Jerusalem.
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Journal ArticleDOI
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
Raphael Mechoulam,Shimon Ben-Shabat,Lumir Hanus,Moshe Ligumsky,Norbert E. Kaminski,Anthony R. Schatz,Asher Gopher,Shlomo Almog,Billy R. Martin,David R. Compton,Roger G. Pertwee,Graeme Griffin,Michael Bayewitch,Jacob Barg,Zvi Vogel +14 more
TL;DR: Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature.
Journal ArticleDOI
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
David Panikashvili,Constantina Simeonidou,Shimon Ben-Shabat,Lumir Hanus,Aviva Breuer,Raphael Mechoulam,Esther Shohami +6 more
TL;DR: It is shown that, after injury to the mouse brain, 2-AG may have a neuroprotective role in which the cannabinoid system is involved and this effect was dose-dependently attenuated by SR-141761A, an antagonist of the CB1 cannabinoid receptor.
Journal ArticleDOI
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.
Shimon Ben-Shabat,Ester Fride,Tzviel Sheskin,Tsippy Tamiri,Man Hee Rhee,Zvi Vogel,Tiziana Bisogno,Luciano De Petrocellis,Vincenzo Di Marzo,Raphael Mechoulam +9 more
TL;DR: The data indicate that the biological activity of 2-Ara-Gl can be increased by related, endogenous 2-acyl-glycerols, which alone show no significant activity in any of the tests employed, suggesting that this effect ('entourage effect') may represent a novel route for molecular regulation of endogenous cannabinoid activity.
Journal Article
Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.
Janet R. Sparrow,Jilin Zhou,Shimon Ben-Shabat,Heidi R. Vollmer,Yasuhiro Itagaki,Koji Nakanishi +5 more
TL;DR: The augmentation of cell death in the presence of D(2)O and the protection afforded by quenchers and scavengers of singlet oxygen, indicates that the generation of Singlet oxygen may be involved in the mechanisms leading to the death of A2E-containing RPE cells after blue light illumination.
Journal ArticleDOI
The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane.
TL;DR: In reaction mixtures of retinal and outer segments and in samples of Royal College of Surgeons rat retina containing outer segment membranous debris, A2-PE was detected as a series of high performance liquid chromatography peaks, each with UV similar to reference A1-PE, thus confirming A2 -PE as the A2E precursor.