Osamu Hori

TL;DR: In this article, the authors demonstrate that inhibition of RAGE-amphoterin interaction suppressed activation of p44/p42, p38 and SAP/JNK MAP kinases; molecular effector mechanisms importantly linked to tumour proliferation, invasion and expression of matrix metalloproteinases.

TL;DR: The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.

TL;DR: Differential manifestation of ER stress and DHA responsiveness may help explain variable clinical results obtained with the use of DHA treatment and suggests that DHA may in fact be effective for a subset of patients.

TL;DR: Data indicate that RAGE has physiologically relevant ligands distinct from AGEs which are likely, via their interaction with the receptor, to participate in physiologic processes outside of the context of diabetes and accumulation of AAGEs.

TL;DR: In this article, the authors hypothesized that formation of advanced glycation end products (AGEs) on the surface of diabetic erythrocytes could mediate their interaction with ECs leading to binding and induction of vascular dysfunction.