P
Parthasarathy Seshacharyulu
Researcher at University of Nebraska Medical Center
Publications - 49
Citations - 2837
Parthasarathy Seshacharyulu is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 22, co-authored 39 publications receiving 2072 citations. Previous affiliations of Parthasarathy Seshacharyulu include Eppley Institute for Research in Cancer and Allied Diseases.
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Journal ArticleDOI
Targeting the EGFR signaling pathway in cancer therapy
Parthasarathy Seshacharyulu,Moorthy P. Ponnusamy,Dhanya Haridas,Maneesh Jain,Apar Kishor Ganti,Surinder K. Batra +5 more
TL;DR: A further understanding of the system is required to develop an effective anticancer regimen and a combination therapy that comprises an anti-EGFR and a chemotherapeutic/chemopreventive agent will exhibit a multi-pronged approach that can be developed into a highly attractive and specific molecular oriented remedy.
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Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
TL;DR: The mouse models developed to understand the biological role of PP2A subunits in an in vivo model system are reviewed in this article and its expression pattern in cancer is summarized.
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Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins
Rolen M. Quadros,Hiromi Miura,Donald W. Harms,Hisako Akatsuka,Takehito Sato,Tomomi Aida,Tomomi Aida,Ronald Redder,Guy P. Richardson,Yutaka Inagaki,Daisuke Sakai,Shannon M. Buckley,Parthasarathy Seshacharyulu,Surinder K. Batra,Mark A. Behlke,Sarah A. Zeiner,Ashley M. Jacobi,Yayoi Izu,Wallace B. Thoreson,Lisa D. Urness,Suzanne L. Mansour,Masato Ohtsuka,Masato Ohtsuka,Channabasavaiah B. Gurumurthy +23 more
TL;DR: Easi-CRISPR solves the major problem of animal genome engineering, namely the inefficiency of targeted DNA cassette insertion, as treating an average of only 50 zygotes is sufficient to produce a correctly targeted allele in up to 100% of live offspring.
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MUC16: molecular analysis and its functional implications in benign and malignant conditions
Dhanya Haridas,Moorthy P. Ponnusamy,Seema Chugh,Imayavaramban Lakshmanan,Parthasarathy Seshacharyulu,Surinder K. Batra +5 more
TL;DR: In this review, the various aspects of MUC16 are discussed, which include its discovery, structure, and biological significance both in benign and malignant conditions with an attempt to dissect its functional relevance.
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Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer.
Satyanarayana Rachagani,Muzafar A. Macha,Nicholas Heimann,Parthasarathy Seshacharyulu,Dhanya Haridas,Seema Chugh,Surinder K. Batra +6 more
TL;DR: The role of several miRNAs that regulate various oncogenes and tumor suppressor genes involved in PC development are summarized, their prospective roles as diagnostic and prognostic markers and as a therapeutic targets are summarized.