Patrick Steigemann

TL;DR: In several human and mouse cancer cell lines and carcinomas, a sapienate biosynthesis pathway underpins metabolic plasticity by allowing these cells to bypass stearoyl-CoA desaturase-dependent fatty acid desaturation.

TL;DR: In a small molecule screen, phosphodiesterase type 5 (PDE5) inhibition was identified as potential strategy to target CSC maintenance and survival in multiple cancer cell lines and a novel mechanism in which PDE5 inhibition leads to elevated cGMP levels that stimulate cAMP/PKA signaling to eliminate CSCs was suggested.

TL;DR: The here presented data suggest a novel, yet unexplored mechanism in which induction of sphingolipid stress leads to the overactivation of hypoxia stress-response pathways and thereby promotes their pro-apoptotic tumor-suppressor functions to specifically kill cells in hypoxic tumor areas.

TL;DR: This study shows condensate-like states of fluorescently labeled structural mutant p53 in the nucleus of living cancer cells and identified small molecule compounds that interact with the p53 protein and lead to dissolution of p53 structural mutant condensates.

TL;DR: A computationally driven approach aimed at identifying novel and selective KRASG12C covalent inhibitors is reported here.