P
Pieter Wesseling
Researcher at University of Amsterdam
Publications - 394
Citations - 35249
Pieter Wesseling is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 78, co-authored 360 publications receiving 26189 citations. Previous affiliations of Pieter Wesseling include Radboud University Nijmegen Medical Centre & Harvard University.
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Journal ArticleDOI
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
Roger Stupp,Monika E. Hegi,Warren P. Mason,Martin J. van den Bent,Martin J.B. Taphoorn,Robert C. Janzer,Samuel K. Ludwin,Anouk Allgeier,Barbara Fisher,Karl Belanger,Peter Hau,Alba A. Brandes,J.M.M. Gijtenbeek,Christine Marosi,Charles J. Vecht,Karima Mokhtari,Pieter Wesseling,Salvador Villà,Elizabeth Eisenhauer,Thierry Gorlia,Michael Weller,Denis Lacombe,J. Gregory Cairncross,René-Olivier Mirimanoff +23 more
TL;DR: Benefits of adjuvant temozolomide with radiotherapy lasted throughout 5 years of follow-up, and a benefit of combined therapy was recorded in all clinical prognostic subgroups, including patients aged 60-70 years.
Journal ArticleDOI
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.
David N. Louis,Arie Perry,Pieter Wesseling,Daniel J. Brat,Ian A. Cree,Dominique Figarella-Branger,Cynthia Hawkins,Ho Keung Ng,Stefan M. Pfister,Guido Reifenberger,Riccardo Soffietti,Andreas von Deimling,Andreas von Deimling,David W. Ellison +13 more
TL;DR: The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spinal cord tumors as mentioned in this paper.
Journal ArticleDOI
DNA methylation-based classification of central nervous system tumours
David Capper,David Capper,David Capper,David T.W. Jones,Martin Sill,Volker Hovestadt,Daniel Schrimpf,Daniel Schrimpf,Dominik Sturm,Dominik Sturm,Christian Koelsche,Christian Koelsche,Felix Sahm,Felix Sahm,Lukas Chavez,David E. Reuss,David E. Reuss,Annekathrin Kratz,Annekathrin Kratz,Annika K. Wefers,Annika K. Wefers,Kristin Huang,Kristin Huang,Kristian W. Pajtler,Kristian W. Pajtler,Leonille Schweizer,Leonille Schweizer,Damian Stichel,Damian Stichel,Adriana Olar,Nils W. Engel,Nils W. Engel,Kerstin Lindenberg,Patrick N. Harter,Patrick N. Harter,Anne K. Braczynski,Anne K. Braczynski,Karl H. Plate,Karl H. Plate,Hildegard Dohmen,Boyan K. Garvalov,Roland Coras,Annett Hölsken,Ekkehard Hewer,Melanie Bewerunge-Hudler,Matthias Schick,Roger Fischer,Rudi Beschorner,Jens Schittenhelm,Ori Staszewski,Khalida Wani,Pascale Varlet,Mélanie Pagès,Petra Temming,Dietmar R. Lohmann,Florian Selt,Florian Selt,Hendrik Witt,Hendrik Witt,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Eleonora Aronica,Felice Giangaspero,Elisabeth J. Rushing,Wolfram Scheurlen,Christoph Geisenberger,Christoph Geisenberger,Fausto J. Rodriguez,Albert J. Becker,Matthias Preusser,Christine Haberler,Rolf Bjerkvig,Jane Cryan,Michael A. Farrell,Martina Deckert,Jürgen Hench,Stephan Frank,Jonathan Serrano,Kasthuri Kannan,Aristotelis Tsirigos,Wolfgang Brück,Silvia Hofer,Stefanie Brehmer,Marcel Seiz-Rosenhagen,Daniel Hänggi,Volkmar Hans,Stephanie Rozsnoki,Jordan R. Hansford,Patricia Kohlhof,Bjarne Winther Kristensen,Matt Lechner,Beatriz Lopes,Christian Mawrin,Ralf Ketter,Andreas E. Kulozik,Ziad Khatib,Frank L. Heppner,Arend Koch,Anne Jouvet,Catherine Keohane,Helmut Mühleisen,Wolf Mueller,Ute Pohl,Marco Prinz,Axel Benner,Marc Zapatka,Nicholas G. Gottardo,Nicholas G. Gottardo,Pablo Hernáiz Driever,Christof M. Kramm,Hermann L. Müller,Stefan Rutkowski,Katja von Hoff,Michael C. Frühwald,Astrid Gnekow,Gudrun Fleischhack,Stephan Tippelt,Gabriele Calaminus,Camelia-Maria Monoranu,Arie Perry,Chris Jones,Thomas S. Jacques,Bernhard Radlwimmer,Marco Gessi,Torsten Pietsch,Johannes Schramm,Gabriele Schackert,Manfred Westphal,Guido Reifenberger,Guido Reifenberger,Pieter Wesseling,Pieter Wesseling,Michael Weller,Vincent Peter Collins,Ingmar Blümcke,Martin Bendszus,Jürgen Debus,Annie Huang,Nada Jabado,Paul A. Northcott,Werner Paulus,Amar Gajjar,Giles W. Robinson,Michael D. Taylor,Zane Jaunmuktane,Marina Ryzhova,Michael Platten,Andreas Unterberg,Wolfgang Wick,Matthias A. Karajannis,Michel Mittelbronn,Till Acker,Christian Hartmann,Kenneth Aldape,Ulrich Schüller,Ulrich Schüller,Rolf Buslei,Peter Lichter,Marcel Kool,Christel Herold-Mende,David W. Ellison,Martin Hasselblatt,Matija Snuderl,Sebastian Brandner,Andrey Korshunov,Andrey Korshunov,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister +171 more
TL;DR: This work presents a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and shows that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods.
Journal ArticleDOI
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
Genevieve Schindler,David Capper,David Capper,Jochen Meyer,Wibke G. Janzarik,Heymut Omran,Christel Herold-Mende,Kirsten Schmieder,Pieter Wesseling,Christian Mawrin,Martin Hasselblatt,David N. Louis,Andrey Korshunov,Stefan M. Pfister,Stefan M. Pfister,Christian Hartmann,Christian Hartmann,Werner Paulus,Guido Reifenberger,Andreas von Deimling,Andreas von Deimling +20 more
TL;DR: The high mutation frequencies in pleomorphic xanthoastrocytomas, gangliogliomas and extra-cerebellar pilocytic astrocyTomas implicate BRAFV600E mutation as a valuable diagnostic marker for these rare tumor entities.
Journal ArticleDOI
Overcoming the blood-brain tumor barrier for effective glioblastoma treatment
O. van Tellingen,B. Yetkin-Arik,M.C. de Gooijer,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger,H.E. de Vries +7 more
TL;DR: Methods to overcome the blood-brain tumor barrier barrier (BBTB) are provided, including osmotic blood- brain barrier disruption (BBBD), bradykinin receptor-mediated BBTB opening, inhibition of multidrug efflux transporters, receptor- mediated transport systems and physiological circumvention of the BBTB.