R
Rémy Burcelin
Researcher at French Institute of Health and Medical Research
Publications - 208
Citations - 33061
Rémy Burcelin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 73, co-authored 203 publications receiving 28240 citations. Previous affiliations of Rémy Burcelin include University of Lausanne & Institut national de la recherche agronomique.
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Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
Journal ArticleDOI
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Patrice D. Cani,Rodrigo Bibiloni,Claude Knauf,Aurélie Waget,Audrey M. Neyrinck,Nathalie M. Delzenne,Rémy Burcelin +6 more
TL;DR: It is found that changes of gut microbiota induced by an antibiotic treatment reduced metabolic endotoxemia and the cecal content of LPS in both high-fat–fed and ob/ob mice, demonstrating that changes in gut microbiota controls metabolic endotoxinemia, inflammation, and associated disorders by a mechanism that could increase intestinal permeability.
Journal ArticleDOI
Host-Gut Microbiota Metabolic Interactions
Jeremy K. Nicholson,Elaine Holmes,James Kinross,Rémy Burcelin,Glenn R. Gibson,Wei Jia,Sven Pettersson +6 more
TL;DR: A deeper understanding of the axes that physiologically connect the gut, liver, muscle, and brain are a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
Journal ArticleDOI
Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.
Patrice D. Cani,Audrey M. Neyrinck,Francesca Fava,Claude Knauf,Rémy Burcelin,Kieran Tuohy,Glenn R. Gibson,Nathalie M. Delzenne,Nathalie M. Delzenne +8 more
TL;DR: The findings suggest that the gut microbiota contribute towards the pathophysiological regulation of endotoxaemia and set the tone of inflammation for occurrence of diabetes and/or obesity.
Journal ArticleDOI
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu,Eduardo Esteve,Eduardo Esteve,Valentina Tremaroli,Muhammad Tanweer Khan,Robert Caesar,Louise Mannerås-Holm,Marcus Ståhlman,Lisa M. Olsson,Matteo Serino,Mercè Planas-Fèlix,Gemma Xifra,Gemma Xifra,Josep M. Mercader,David Torrents,David Torrents,Rémy Burcelin,Rémy Burcelin,Wifredo Ricart,Wifredo Ricart,Rosie Perkins,José Manuel Fernández-Real,José Manuel Fernández-Real,Fredrik Bäckhed,Fredrik Bäckhed,Fredrik Bäckhed +25 more
TL;DR: It is shown that metformin affected pathways with common biological functions in species from two different phyla, and many of the met formin-regulated genes in these species encoded metalloproteins or metal transporters, which provides support for the notion that altered gut microbiota mediates some of metformIn's antidiabetic effects.