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Aurélie Waget
Researcher at French Institute of Health and Medical Research
Publications - 32
Citations - 12996
Aurélie Waget is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Insulin resistance & Adipose tissue. The author has an hindex of 25, co-authored 31 publications receiving 10948 citations. Previous affiliations of Aurélie Waget include Paul Sabatier University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
Journal ArticleDOI
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Patrice D. Cani,Rodrigo Bibiloni,Claude Knauf,Aurélie Waget,Audrey M. Neyrinck,Nathalie M. Delzenne,Rémy Burcelin +6 more
TL;DR: It is found that changes of gut microbiota induced by an antibiotic treatment reduced metabolic endotoxemia and the cecal content of LPS in both high-fat–fed and ob/ob mice, demonstrating that changes in gut microbiota controls metabolic endotoxinemia, inflammation, and associated disorders by a mechanism that could increase intestinal permeability.
Journal ArticleDOI
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Jacques Amar,Chantal Chabo,Aurélie Waget,Pascale Klopp,Christelle Vachoux,Luis G. Bermúdez-Humarán,Natalia F. Smirnova,Mathieu Bergé,Mathieu Bergé,Thierry Sulpice,Sampo J. Lahtinen,Arthur C. Ouwehand,Philippe Langella,Nina Rautonen,Philippe J. Sansonetti,Rémy Burcelin +15 more
TL;DR: It is demonstrated that the early onset of HFD‐induced hyperglycemia is characterized by an increased bacterial translocation from intestine towards tissues, fuelling a continuous metabolic bacteremia, which could represent new therapeutic targets.
Journal ArticleDOI
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
David Sebastián,María Isabel Hernández-Alvarez,Jessica Segalés,Eleonora Sorianello,Juan Pablo Muñoz,David Sala,Aurélie Waget,Marc Liesa,José C. Paz,Peddinti Gopalacharyulu,Matej Orešič,Sara Pich,Rémy Burcelin,Manuel Palacín,Antonio Zorzano +14 more
TL;DR: This study provides an important description of a unique unexpected role of Mfn2 coordinating mitochondria and endoplasmic reticulum function, leading to modulation of insulin signaling and glucose homeostasis in vivo.
Journal ArticleDOI
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
Matteo Serino,Elodie Luche,Sandra Grès,Audrey Baylac,Mathieu Bergé,Claire Cenac,Aurélie Waget,Pascale Klopp,Jason S. Iacovoni,Christophe Klopp,Jérôme Mariette,Olivier Bouchez,Jérôme Lluch,Françoise Ouarné,Pierre Monsan,Philippe Valet,Christine Roques,Jacques Amar,Anne Bouloumié,Vassilia Theodorou,Rémy Burcelin +20 more
TL;DR: The HFD-D gut microbial profile was associated with increased gut permeability linked to increased endotoxaemia and to a dramatic increase in cell number in the stroma vascular fraction from visceral white adipose tissue.