Roland Moll

TL;DR: Since keratins also exhibit characteristic expression patterns in human tumors, several of them have great importance in immunohistochemical tumor diagnosis of carcinomas, in particular of unclear metastases and in precise classification and subtyping.

TL;DR: The results show that synaptophysin, and the vesicles that contain it, can occur in normal and neoplastic neuroendocrine cells of neural type, as demonstrated by colocalization with neurofilaments, as well as in those of epithelial type, including cytokeratin filaments and desmoplakins.

TL;DR: The MYC proto-oncogene encodes a transcription factor that has been implicated in the genesis of many human tumours and one of these genes encodes USP28, an ubiquitin-specific protease required for MYC stability in human tumour cells.

TL;DR: A previously unidentified cell population within the epithelial compartment of the breast, which displays the phenotypic characteristics of a committed stem cell, is visualized, which might serve as a tool to unravel the regulatory mechanisms that govern regeneration and abnormal proliferation of breast epithelium at the cellular level.

TL;DR: Combination treatment was not superior to monotherapy concerning progression-free and long-term survival in patients with progressive metastatic neuroendocrine foregut and midgut tumors; patients responding to treatment and those with slow spontaneous tumor growth had a survival advantage.