Rumen V. Kostov

TL;DR: This review focuses on the animal studies demonstrating the beneficial effects of glucosinolates and isothiocyanates in models of carcinogenesis, and cardiovascular and neurological diseases, as well as on the intervention studies of their safety, pharmacokinetics, and efficacy in humans.

TL;DR: Small molecule activators of Nrf2 support mitochondrial integrity by promoting mitophagy and conferring resistance to oxidative stress-mediated permeability transition, with implications for stem cell self-renewal, cardiomyocyte regeneration, and neural stem/progenitor cell survival.

TL;DR: The early studies leading to the prediction of the existence of Keap1, followed by the discovery ofKeap1 as the main negative regulator of Nrf2 are summarized and the available structural information on Keap 1, its assembly with Cullin3, and its interaction with Nrf 2 are described.

TL;DR: Targeting Nrf2 signaling may provide a therapeutic option to delay onset, slow progression, and ameliorate symptoms of neurodegenerative disorders.

TL;DR: This review summarizes the chemical biology of sulforaphane as an inducer of NRF2 signaling and efficacy as an inhibitor of carcinogenesis and provides a summary of the current findings from clinical trials using a suite of broccoli sprout preparations on a series of short-term endpoints reflecting a diversity of molecular actions.