K
Kira M. Holmström
Researcher at National Institutes of Health
Publications - 26
Citations - 7648
Kira M. Holmström is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mitochondrion & Calcium. The author has an hindex of 22, co-authored 26 publications receiving 6401 citations. Previous affiliations of Kira M. Holmström include University of Helsinki & University of Tübingen.
Papers
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Journal ArticleDOI
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler,Kira M. Holmström,Diana Skujat,Fabienne C. Fiesel,Oliver Rothfuss,Philipp J. Kahle,Wolfdieter Springer +6 more
TL;DR: Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
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Cellular mechanisms and physiological consequences of redox-dependent signalling
Kira M. Holmström,Toren Finkel +1 more
TL;DR: The sources of ROS within cells and what is known regarding how intracellular oxidant levels are regulated are discussed, with the recent observations that reduction–oxidation (redox)-dependent regulation has a crucial role in an ever-widening range of biological activities.
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Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin
Nicole Exner,Bettina Treske,Dominik Paquet,Kira M. Holmström,Carola Schiesling,Suzana Gispert,Iria Carballo-Carbajal,Daniela Berg,Hans-Hermann Hoepken,Thomas Gasser,Rejko Krüger,Konstanze F. Winklhofer,Frank Vogel,Andreas S. Reichert,Georg Auburger,Philipp J. Kahle,Bettina Schmid,Christian Haass +17 more
TL;DR: The results may suggest that PINK1 deficiency in humans results in mitochondrial abnormalities associated with cellular stress, a pathological phenotype, which can be ameliorated by enhanced expression of parkin.
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Measuring In Vivo Mitophagy
Nuo Sun,Jeanho Yun,Jie Liu,Daniela Malide,Chengyu Liu,Ilsa I. Rovira,Kira M. Holmström,Maria M. Fergusson,Young Hyun Yoo,Christian A. Combs,Toren Finkel +10 more
TL;DR: A transgenic mouse model in which a mitochondrial-targeted form of the fluorescent reporter Keima was expressed, a coral-derived protein that exhibits both pH-dependent excitation and resistance to lysosomal proteases, is described, suggesting that the mt-Keima mouse should be a valuable resource.
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Nrf2 regulates ROS production by mitochondria and NADPH oxidase
Stjepana Kovac,Plamena R. Angelova,Kira M. Holmström,Ying Zhang,Albena T. Dinkova-Kostova,Andrey Y. Abramov +5 more
TL;DR: It is suggested that the Keap1–Nrf2 pathway regulates both mitochondrial and cytosolic ROS production through NADPH oxidase, which supports a key role of the KeAP1-NRF2 pathway in redox homeostasis within the cell.