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Albena T. Dinkova-Kostova

Researcher at University of Dundee

Publications -  213
Citations -  26405

Albena T. Dinkova-Kostova is an academic researcher from University of Dundee. The author has contributed to research in topics: KEAP1 & Transcription factor. The author has an hindex of 71, co-authored 188 publications receiving 20455 citations. Previous affiliations of Albena T. Dinkova-Kostova include Ninewells Hospital & Johns Hopkins University Applied Physics Laboratory.

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Journal ArticleDOI

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova-Kostova, +7 more
- 03 Sep 2002 - 
TL;DR: This finding suggests that reaction of cysteine thiols is followed by rapid formation of protein disulfide linkages, which are the direct sensors of inducers of the phase 2 system.
Journal ArticleDOI

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

John D. Hayes, +1 more
- 01 Apr 2014 - 
TL;DR: Observations suggest Nrf2 directs metabolic reprogramming during stress, which would enable the factor to orchestrate adaptive responses to diverse forms of stress.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Evanna L. Mills, +38 more
- 05 Apr 2018 - 
TL;DR: It is shown that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 by lipopolysaccharide in mouse and human macrophages and that type I interferons boost the expression of Irg1 (also known as Acod1) and itaconates production.
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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

Nobunao Wakabayashi, +7 more
- 17 Feb 2004 - 
TL;DR: Evidence for formation of intermolecular disulfide bridges was obtained by 2D PAGE of extracts of cells treated with inducers, and by the demonstration that whereas C273A and C288A mutants of Keap1 alone could not repress Nrf2 activation of the ARE-luciferase reporter, an equal mixture of these mutant constructs restored repressor activity.