Sasikumar J. Soumya

TL;DR: This work has developed the first comprehensive map of endothelial cell-specific signaling events of VEGFA/VEGFR2 system pertaining to angiogenesis and believes that this map would serve as a novel platform for reference, integration, and representation and more significantly, the progressive analysis of dynamic features of V EGF signaling in endothelial cells including their cross-talks with other ligand-receptor systems involved inAngiogenesis.

TL;DR: Observations suggest that 15(S)-HETE stimulates angiogenesis in adipose tissue through activation of PI3K/Akt/mTOR signaling.

TL;DR: The divergent effects of hydroxy and hydroperoxy products of 15-LOX on angiogenesis are indicated, highlighting the role of these products in the co-dependence of inflammation andAngiogenesis.

TL;DR: Citrate induced significant upregulation and activation of Akt in endothelial cells, and Rapamycin, an inhibitor of mTOR, reversed the effect of citrate in human umbilical vein endothelial Cells and sprouting of aortic rings suggesting that the angiogenic effect ofcitrate involves activation of PI3K–Akt–mTOR pathway.

TL;DR: Effect of metabolites, as exemplified by certain metabolites such as lactate, citrate, sarcosine, metabolites of arachidonic acid on angiogenesis through the regulation of expression of VEGF as well as its angiogenic potential through polyADP ribosylation is discussed.