T
Tong-Chuan He
Researcher at University of Chicago
Publications - 395
Citations - 37992
Tong-Chuan He is an academic researcher from University of Chicago. The author has contributed to research in topics: Mesenchymal stem cell & Cellular differentiation. The author has an hindex of 80, co-authored 361 publications receiving 33709 citations. Previous affiliations of Tong-Chuan He include Chongqing Medical University & Boston Children's Hospital.
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Journal ArticleDOI
Identification of c-MYC as a Target of the APC Pathway
Tong-Chuan He,Andrew B. Sparks,Carlo Rago,Heiko Hermeking,Leigh Zawel,Luis T. da Costa,Patrice J. Morin,Bert Vogelstein,Kenneth W. Kinzler +8 more
TL;DR: The c-MYC oncogene is identified as a target gene in this signaling pathway and shown to be repressed by wild-type APC and activated by beta-catenin, and these effects were mediated through Tcf-4 binding sites in the c- MYC promoter.
PatentDOI
A simplified system for generating recombinant adenoviruses
TL;DR: In this paper, a recombinant adenoviral plasmid is generated with a minimum of enzymatic manipulations, employing homologous recombination in bacteria rather than in eucaryotic cells.
Journal ArticleDOI
14-3-3σ Is a p53-Regulated Inhibitor of G2/M Progression
Heiko Hermeking,Christoph Lengauer,Kornelia Polyak,Tong-Chuan He,Lin Zhang,Sam Thiagalingam,Kenneth W. Kinzler,Bert Vogelstein +7 more
TL;DR: It is discovered that 14-3-3σ is strongly induced by γ irradiation and other DNA-damaging agents, and mediated by a p53-responsive element located 1.8 kb upstream of its transcription start site.
Journal ArticleDOI
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,Gary L. Gallia,Beppino C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,Ralph H. Hruban,George I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.K. Ahmed Rasheed,Gregory J. Riggins,Thomas A. Rosenquist,Mark Schiffman,Ie Ming Shih,Dan Theodorescu,Michael Torbenson,Victor E. Velculescu,Tian Li Wang,Nicolas Wentzensen,Laura D. Wood,Ming Zhang,Roger E. McLendon,Darell D. Bigner,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Hai Yan +36 more
TL;DR: TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs
TL;DR: Findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARdelta, the gene for which is normally regulated by APC.