Werner Hohenberger

TL;DR: DNA stool test of hypermethylation of the secreted frizzled-related protein-1 promoter is a sensitive and specific method that has the potential of a clinically useful test for the early detection of colorectal cancer.

TL;DR: 60 polypeptides – including proteins specifically expressed in colorectal epithelium – have now been identified using gel matching, N‐terminal sequencing and/or immunoblotting techniques, and this reproducible method of sample preparation permits the comparison of protein patterns found in various pathological states with the present reference map.

TL;DR: In this article, only surgical treatment carried out in curative intent will be considered, which means that all patients with established distant metastases and those receiving palliative resections because of local residual tumor are excluded.

TL;DR: NAR score could help oncologists to speed up response-adapted therapeutic decision, and further large phase III trial data sets should aim to confirm trial-level surrogacy.

TL;DR: Data provide further support for the hypothesis that MSI-H CRC might have a better response and survival than (MSS) CRC in palliative first-line treatment.