T
Thomas Brabletz
Researcher at University of Erlangen-Nuremberg
Publications - 179
Citations - 27614
Thomas Brabletz is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 64, co-authored 172 publications receiving 23946 citations. Previous affiliations of Thomas Brabletz include German Cancer Research Center & University Medical Center Freiburg.
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Journal ArticleDOI
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
TL;DR: Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.
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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Ulrich F. Wellner,Jörg Schubert,Ulrike Burk,Otto Schmalhofer,Feng Zhu,Annika G Sonntag,Bettina Waldvogel,Corinne Vannier,Douglas S. Darling,Axel zur Hausen,Valerie G. Brunton,Jennifer P. Morton,Owen J. Sansom,Julia Schüler,Marc P. Stemmler,Christoph Herzberger,Ulrich T. Hopt,Tobias Keck,Simone Brabletz,Thomas Brabletz +19 more
TL;DR: It is proposed that ZEB1 links EMT-activation and stemness-maintenance by suppressingstemness-inhibiting microRNAs (miRNAs) and thereby is a promoter of mobile, migrating cancer stem cells.
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EMT in cancer
TL;DR: Four scientists have been asked for their opinions on the role of EMT in cancer and the challenges faced by scientists working in this fast-moving field.
Journal Article
Migrating cancer stem cells: An integrated concept of malignant tumor progression.
TL;DR: In this article, it was shown that the EMT-associated tumor cells at the invasive front act as migrating cancer stem cells, which can re-differentiate and, depending on the range of dissemination, give raise to the primary carcinoma or metastases.
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Migrating cancer stem cells — an integrated concept of malignant tumour progression
TL;DR: An extended, integrated model that is consistent with all aspects of human tumour progression is suggested — the 'migrating cancer stem (MCS)-cell' concept.