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Ximena Paredes-Gonzalez
Researcher at Rutgers University
Publications - 10
Citations - 726
Ximena Paredes-Gonzalez is an academic researcher from Rutgers University. The author has contributed to research in topics: Epigenetics & CpG site. The author has an hindex of 8, co-authored 10 publications receiving 572 citations.
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Journal ArticleDOI
The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway
Constance Lay Lay Saw,Yue Guo,Anne Yuqing Yang,Ximena Paredes-Gonzalez,Christina N. Ramirez,Douglas Pung,Ah-Ng Tony Kong +6 more
TL;DR: This study demonstrated that the berry constituents quercetin, kaempferol, and pterostilbene activated the Nrf2-ARE signaling pathway and exhibited synergistic anti-oxidative stress activity at appropriate concentrations.
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Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy
TL;DR: The cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis is summarized, with particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo human cancer animal models.
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Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications.
TL;DR: Results showed that API can restore the silenced status of Nrf2 in skin epidermal JB6 P + cells by CpG demethylation coupled with attenuated DNMT and HDAC activity.
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Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin
Sarandeep S.S. Boyanapalli,Ximena Paredes-Gonzalez,Francisco Fuentes,Chengyue Zhang,Yue Guo,Doug Pung,Constance Lay Lay Saw,Ah-Ng Tony Kong +7 more
TL;DR: The results from qPCR, western blot, and ELISA analyses in macrophages indicate that Nrf2 plays an important role in the anti-inflammatory and antioxidative effects of PEITC and CUR, as observed by their decreased activities in NRF2–/– macrophage.
Journal ArticleDOI
Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin
Ximena Paredes-Gonzalez,Francisco Fuentes,Sundrina Jeffery,Constance Lay Lay Saw,Limin Shu,Zheng-Yuan Su,Ah-Ng Tony Kong +6 more
TL;DR: The results indicate that API and LUT significantly activate the PI3K/Nrf2/ARE system, and this activation may be responsible for their antiinflammatory effects, as demonstrated by the suppression of LPS‐induced NO, iNOS and cPLA2.