Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy
TLDR
The cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis is summarized, with particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo human cancer animal models.Abstract:
Glucosinolates are a group of sulfur-containing glycosides found in many plant species, including cruciferous vegetables such as broccoli, cabbage, brussels sprouts, and cauliflower. Accumulating evidence increasingly supports the beneficial effects of dietary glucosinolates on overall health, including as potential anti-cancer agents, because of their role in the prevention of the initiation of carcinogenesis via the induction of cellular defense detoxifying/antioxidant enzymes and their epigenetic mechanisms, including modification of the CpG methylation of cancer-related genes, histone modification regulation and changes in the expression of miRNAs. In this context, the defense mechanism mediated by Nrf2-antioxidative stress and anti-inflammatory signaling pathways can contribute to cellular protection against oxidative stress and reactive metabolites of carcinogens. In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis, with particular emphasis on specific molecular targets and epigenetic alterations in in vitro and in vivo human cancer animal models.read more
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Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase
Zhongbin Deng,Yuan Rong,Yun Teng,Jingyao Mu,Xiaoying Zhuang,Michael T. Tseng,Abhilash Samykutty,Lifeng Zhang,Jun Yan,Donald R. Miller,Jill Suttles,Huang-Ge Zhang,Huang-Ge Zhang +12 more
TL;DR: Evidence is presented supporting the hypothesis that edible nanoparticles regulate intestinal immune homeostasis by targeting dendritic cells (DCs) by activating AMPK, and orally given nanoparticles isolated from broccoli extracts protect mice against colitis.
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Nrf2 mediates redox adaptations to exercise.
TL;DR: The evidence of Nrf2 activation in response to exercise across variety of tissues may be an important mechanism of how exercise exerts its well-known systemic effects that are not limited to skeletal muscle and myocardium.
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Plant-Derived Bioactives and Oxidative Stress-Related Disorders : A Key Trend towards Healthy Aging and Longevity Promotion
Bahare Salehi,Elena Azzini,Paolo Zucca,Elena Maria Varoni,Nanjangud V. Anil Kumar,Luciana Dini,Elisa Panzarini,Jovana Rajkovic,Patrick Valere Tsouh Fokou,Ilaria Peluso,Abhay Prakash Mishra,Manisha Nigam,Youssef El Rayess,Marc El Beyrouthy,William N. Setzer,Letizia Polito,Marcello Iriti,Antoni Sureda,Maria Magdalena Quetglas-Llabrés,Miquel Martorell,Natália Martins,Mehdi Sharifi-Rad,Leticia M. Estevinho,Javad Sharifi-Rad +23 more
TL;DR: The role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion.
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Fruit and vegetable consumption and breast cancer incidence: Repeated measures over 30 years of follow-up.
Maryam S. Farvid,Wendy Y. Chen,Wendy Y. Chen,Bernard Rosner,Rulla M. Tamimi,Rulla M. Tamimi,Walter C. Willett,Walter C. Willett,A. Heather Eliassen,A. Heather Eliassen +9 more
TL;DR: It is found that higher intake of fruits and vegetables, and specifically cruciferous and yellow/orange vegetables, may reduce the risk of breast cancer, especially those that are more likely to be aggressive tumors.
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An overview on neuroprotective effects of isothiocyanates for the treatment of neurodegenerative diseases.
Sabrina Giacoppo,Maria Galuppo,Sabine Montaut,Renato Iori,Patrick Rollin,Placido Bramanti,Emanuela Mazzon +6 more
TL;DR: This review summarizes the current knowledge about the neuroprotective effects of ITCs in counteracting oxidative stress as well as inflammatory and apoptotic mechanisms, using in vitro and in vivo models of acute and chronic neurodegenerative disease.
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