Institution
Aichi Gakuin University
Education•Nagoya, Japan•
About: Aichi Gakuin University is a education organization based out in Nagoya, Japan. It is known for research contribution in the topics: Porphyromonas gingivalis & Population. The organization has 2617 authors who have published 4108 publications receiving 82010 citations. The organization is also known as: Aichi Gakuin Daigaku.
Papers published on a yearly basis
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TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Abstract: To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
954 citations
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TL;DR: Human tissue inhibitor of metalloproteinases‐1 (TIMP‐1), but not TIMP‐2, has potent growth‐promoting activity for a wide range of human and bovine cells, but TIMP-1 seems to be a new cell‐growth factor in serum and to stimulate the cells independently of its inhibitory activity.
728 citations
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TL;DR: Piezo1 channels are shown as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology and the data suggest that Piezo 1 channels function as pivotal integrators in vascular biology.
Abstract: The mechanisms by which physical forces regulate endothelial cells to determine the complexities of vascular structure and function are enigmatic. Studies of sensory neurons have suggested Piezo proteins as subunits of Ca(2+)-permeable non-selective cationic channels for detection of noxious mechanical impact. Here we show Piezo1 (Fam38a) channels as sensors of frictional force (shear stress) and determinants of vascular structure in both development and adult physiology. Global or endothelial-specific disruption of mouse Piezo1 profoundly disturbed the developing vasculature and was embryonic lethal within days of the heart beating. Haploinsufficiency was not lethal but endothelial abnormality was detected in mature vessels. The importance of Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells. Downstream of this calcium influx there was protease activation and spatial reorganization of endothelial cells to the polarity of the applied force. The data suggest that Piezo1 channels function as pivotal integrators in vascular biology.
710 citations
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Academia Sinica1, China Medical University (Taiwan)2, Shanghai Jiao Tong University3, Vanderbilt University4, National University of Singapore5, University of North Carolina at Chapel Hill6, University of Tokyo7, National Taiwan University8, Seoul National University9, The Chinese University of Hong Kong10, Kyushu University11, Singapore National Eye Center12, Fudan University13, Harvard University14, Ewha Womans University15, Soongsil University16, University of San Carlos17, Agency for Science, Technology and Research18, Nagoya University19, University of Melbourne20, Aichi Gakuin University21, Kindai University22, Ajou University23, University of Oxford24, University of California, San Francisco25, Systems Research Institute26
TL;DR: The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.
Abstract: We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.
587 citations
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University of Iowa1, University of Pittsburgh2, University of São Paulo3, University of Southern Denmark4, Aichi Gakuin University5, Nagasaki University6, Federal University of Rio de Janeiro7, Oswaldo Cruz Foundation8, University of Antioquia9, University of British Columbia10, University of Toronto11
TL;DR: DNA-sequence variants associated with IRF6 are major contributors to cleft lip, with or without cleft palate; moreover, the results for some individual populations from South America and Asia were highly significant.
Abstract: Background Cleft lip or palate (or the two in combination) is a common birth defect that results from a mixture of genetic and environmental factors. We searched for a specific genetic factor contributing to this complex trait by examining large numbers of affected patients and families and evaluating a specific candidate gene. Methods We identified the gene that encodes interferon regulatory factor 6 (IRF6) as a candidate gene on the basis of its involvement in an autosomal dominant form of cleft lip and palate, Van der Woude's syndrome. A single-nucleotide polymorphism in this gene results in either a valine or an isoleucine at amino acid position 274 (V274I). We carried out transmission-disequilibrium testing for V274I in 8003 individual subjects in 1968 families derived from 10 populations with ancestry in Asia, Europe, and South America, haplotype and linkage analyses, and case–control analyses, and determined the risk of cleft lip or palate that is associated with genetic variation in IRF6. Results ...
570 citations
Authors
Showing all 2627 results
Name | H-index | Papers | Citations |
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Toyoaki Murohara | 92 | 1190 | 49931 |
Toshiharu Nagatsu | 87 | 814 | 32406 |
Takashi Muramatsu | 84 | 444 | 22930 |
Mary L. Marazita | 77 | 436 | 21909 |
Hiroyoshi Hidaka | 73 | 494 | 24619 |
Norio Ozaki | 68 | 658 | 21198 |
Hiroyuki Osada | 67 | 651 | 18192 |
Hiroyuki Nawa | 66 | 219 | 15994 |
Makoto Asashima | 63 | 417 | 15053 |
Toshio Ogihara | 54 | 179 | 9690 |
Tadaaki Nagao | 49 | 302 | 7566 |
Hiroshi Ikegami | 48 | 245 | 9812 |
Satoshi Inouye | 48 | 181 | 8702 |
Hiromitsu Yamamoto | 46 | 128 | 7390 |
Wakako Maruyama | 45 | 94 | 5414 |