Chiba University

About: Chiba University is a education organization based out in Chiba, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 27201 authors who have published 51441 publications receiving 1172877 citations. The organization is also known as: Chiba Daigaku.

Global Change Observation Mission (GCOM) for Monitoring Carbon, Water Cycles, and Climate Change

Abstract: The Japan Aerospace Exploration Agency (JAXA) is pursuing the Global Change Observation Mission (GCOM) that will inherit the Advanced Earth Observing Satellite-II (ADEOS-II) mission and develop into long-term monitoring. GCOM is not the name of a single satellite, but of a mission that consists of two series of medium-size satellites, GCOM-W (Water) and GCOM-C (Climate), and three generations of each satellite series to continue the observations for 10 to 15 years. The Advanced Microwave Scanning Radiometer-2 (AMSR2) will be the single instrument on the GCOM-W1 satellite, which is the first satellite of the GCOM series. The second satellite will be GCOM-C1, which will carry the Second-generation Global Imager (SGLI). GCOM-W will mainly contribute to the observations related to global water and energy circulation, while GCOM-C will contribute to the measurements related to the carbon cycle and radiation budget. Current target launch years are calendar year 2011 for GCOM-W1 and 2014 for C1.

Carbonyl Compounds Generated from Electronic Cigarettes

Abstract: Electronic cigarettes (e-cigarettes) are advertised as being safer than tobacco cigarettes products as the chemical compounds inhaled from e-cigarettes are believed to be fewer and less toxic than those from tobacco cigarettes. Therefore, continuous careful monitoring and risk management of e-cigarettes should be implemented, with the aim of protecting and promoting public health worldwide. Moreover, basic scientific data are required for the regulation of e-cigarette. To date, there have been reports of many hazardous chemical compounds generated from e-cigarettes, particularly carbonyl compounds such as formaldehyde, acetaldehyde, acrolein, and glyoxal, which are often found in e-cigarette aerosols. These carbonyl compounds are incidentally generated by the oxidation of e-liquid (liquid in e-cigarette; glycerol and glycols) when the liquid comes in contact with the heated nichrome wire. The compositions and concentrations of these compounds vary depending on the type of e-liquid and the battery voltage. In some cases, extremely high concentrations of these carbonyl compounds are generated, and may contribute to various health effects. Suppliers, risk management organizations, and users of e-cigarettes should be aware of this phenomenon.

Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.

Abstract: Major depressive disorder (MDD) is one of the most disabling psychiatric disorders. Approximately one-third of the patients with MDD are treatment resistant to the current antidepressants. There is also a significant therapeutic time lag of weeks to months. Furthermore, depression in patients with bipolar disorder (BD) is typically poorly responsive to antidepressants. Therefore, there exists an unmet medical need for rapidly acting antidepressants with beneficial effects in treatment-resistant patients with MDD or BD. Accumulating evidence suggests that the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine produces rapid and sustained antidepressant effects in treatment-resistant patients with MDD or BD. Ketamine is a racemic mixture comprising equal parts of (R)-ketamine (or arketamine) and (S)-ketamine (or esketamine). Because (S)-ketamine has higher affinity for NMDAR than (R)-ketamine, esketamine was developed as an antidepressant. On 5 March 2019, esketamine nasal spray was approved by the US Food and Drug Administration. However, preclinical data suggest that (R)-ketamine exerts greater potency and longer-lasting antidepressant effects than (S)-ketamine in animal models of depression and that (R)-ketamine has less detrimental side-effects than (R,S)-ketamine or (S)-ketamine. In this article, the author reviews the historical overview of the antidepressant actions of enantiomers of ketamine and its major metabolites norketamine and hydroxynorketamine. Furthermore, the author discusses the other potential rapid-acting antidepressant candidates (i.e., NMDAR antagonists and modulators, low-voltage-sensitive T-type calcium channel inhibitor, potassium channel Kir4.1 inhibitor, negative modulators of γ-aminobutyric acid, and type A [GABAA ] receptors) to compare them with ketamine. Moreover, the molecular and cellular mechanisms of ketamine's antidepressant effects are discussed.

Linear Scale-Space has First been Proposed in Japan

Abstract: Linear scale-space is considered to be a modern bottom-up tool in computer vision. The American and European vision community, however, is unaware of the fact that it has already been axiomatically derived in 1959 in a Japanese paper by Taizo Iijima. This result formed the starting point of vast linear scale-space research in Japan ranging from various axiomatic derivations over deep structure analysis to applications to optical character recognition. Since the outcomes of these activities are unknown to western scale-space researchers, we give an overview of the contribution to the development of linear scale-space theories and analyses. In particular, we review four Japanese axiomatic approaches that substantiate linear scale-space theories proposed between 1959 and 1981. By juxtaposing them to ten American or European axiomatics, we present an overview of the state-of-the-art in Gaussian scale-space axiomatics. Furthermore, we show that many techniques for analysing linear scale-space have also been pioneered by Japanese researchers.

Phase II Evaluation of Cisplatin and 5-Fluorouracil in Advanced Squamous Cell Carcinoma of the Esophagus: A Japanese Esophageal Oncology Group Trial

Abstract: Thirty-nine patients with advanced measurable squamous cell carcinomas were treated with two or more courses of 70 mg cisplatin/m2 on day 1 and 700 mg infused 5-fluorouracil/m2 on days 1-5 every 21 days. The overall response rate was 35.9 (95% confidence limits, 24.8-55.1%). Responses were seen in primary sites in the esophagus of five patients, in the lung of seven, the liver of one and the mediastinal lymph nodes of one. The average response duration was 3.5 (range 1-12) mo for patients who achieved partial response. The average survival time after the first administration was 9.5 mo for patients who responded to the treatment whereas, for those who did not, it was 5.6 mo. The major form of toxicity was myelosuppression and there were six patients with grade 3 toxicity and one with grade 4. The present study was designed to evaluate the effectiveness of combined cisplatin and 5-fluorouracil for advanced squamous cell carcinoma, and the results showed that it had a reasonable effect and might possibly be used as a postoperative chemotherapy because of its mild side effects.