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Showing papers by "National Academy of Sciences of Ukraine published in 2020"


Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2248 moreInstitutions (155)
TL;DR: For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.
Abstract: New sets of CMS underlying-event parameters (“tunes”) are presented for the pythia8 event generator. These tunes use the NNPDF3.1 parton distribution functions (PDFs) at leading (LO), next-to-leading (NLO), or next-to-next-to-leading (NNLO) orders in perturbative quantum chromodynamics, and the strong coupling evolution at LO or NLO. Measurements of charged-particle multiplicity and transverse momentum densities at various hadron collision energies are fit simultaneously to determine the parameters of the tunes. Comparisons of the predictions of the new tunes are provided for observables sensitive to the event shapes at LEP, global underlying event, soft multiparton interactions, and double-parton scattering contributions. In addition, comparisons are made for observables measured in various specific processes, such as multijet, Drell–Yan, and top quark-antiquark pair production including jet substructure observables. The simulation of the underlying event provided by the new tunes is interfaced to a higher-order matrix-element calculation. For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.

265 citations


Journal ArticleDOI
Milan Chytrý1, Lubomír Tichý1, Stephan M. Hennekens, Ilona Knollová1, John Janssen, John S. Rodwell, Tomáš Peterka1, Corrado Marcenò1, Flavia Landucci1, Jiří Danihelka1, Michal Hájek1, Jürgen Dengler2, Jürgen Dengler3, Pavel Novák1, Dominik Zukal1, Borja Jiménez-Alfaro4, Ladislav Mucina5, Ladislav Mucina6, Sylvain Abdulhak, Svetlana Aćić7, Emiliano Agrillo, Fabio Attorre8, Erwin Bergmeier9, Idoia Biurrun10, Steffen Boch, János Bölöni, Gianmaria Bonari11, Gianmaria Bonari1, Tatiana Braslavskaya12, Helge Bruelheide13, Juan Antonio Campos10, Andraž Čarni14, Andraž Čarni15, Laura Casella, Mirjana Ćuk16, Renata Ćušterevska, Els De Bie17, Pauline Delbosc18, Olga N. Demina, Yakiv Didukh19, Daniel Dítě20, Tetiana Dziuba19, Jörg Ewald, Rosario G. Gavilán21, Jean Claude Gégout22, Gianpietro Giusso del Galdo23, Valentin Golub12, Nadezhda Goncharova12, Friedemann Goral9, Ulrich Graf, Adrian Indreica24, Maike Isermann25, Ute Jandt13, Florian Jansen26, Jan B.M.J. Jansen27, Anni Jašková1, Martin Jiroušek1, Martin Jiroušek28, Zygmunt Kącki29, Veronika Kalníková1, Ali Kavgaci30, Larisa Khanina31, Andrey Yu. Korolyuk12, Mariya Kozhevnikova32, Anna Kuzemko1, Anna Kuzemko19, Filip Küzmič15, Oleg L. Kuznetsov12, Māris Laiviņš33, I. A. Lavrinenko12, O. V. Lavrinenko12, Maria Vladimirovna Lebedeva12, Zdeňka Lososová1, Tatiana Lysenko12, Lise Maciejewski34, Lise Maciejewski22, Constantin Mardari35, Aleksander Marinšek, Maxim G. Napreenko36, Viktor Onyshchenko19, Aaron Pérez-Haase37, Aaron Pérez-Haase38, Remigiusz Pielech39, Vadim Prokhorov32, Valerijus Rašomavičius, Maria Pilar Rodríguez Rojo, Solvita Rūsiņa40, Joachim Schrautzer41, Jozef Šibík20, Urban Šilc15, Željko Škvorc42, Viktor A. Smagin12, Zvjezdana Stančić42, Angela Stanisci43, Elena B. Tikhonova12, Tiina Tonteri, Domas Uogintas, Milan Valachovič20, Kiril Vassilev44, Denys Vynokurov19, Denys Vynokurov1, Wolfgang Willner45, S. M. Yamalov12, Douglas Evans, Mette Palitzsch Lund46, Rania Spyropoulou46, Eleni Tryfon46, Joop H.J. Schaminée 
TL;DR: This article developed the classification expert system EUNIS-ESy, which assigns vegetation plots to European habitats based on their species composition and geographic location. But the system is not suitable for outdoor gardening.
Abstract: EUNIS Habitat Classification is a standard classification of European habitats. We developed the classification expert system EUNIS‐ESy, which assigns vegetation plots to EUNIS habitats based on their species composition and geographic location. We classified 1,261,373 vegetation plots from the European Vegetation Archive and determined characteristic species combinations and prepared distribution maps for 199 habitats at Level 3 of EUNIS hierarchy.

153 citations


Journal ArticleDOI
TL;DR: This review discussed a possible link between the activation of hypoxia inducible factor 1α (HIF-1α) and cell entry of SARS-CoV-2 and hypothesized a potential utility of so-called “hypoxic conditioning” to activate HIF- 1α-induced cytoprotective signaling for reduction of illness severity and improvement of vital organ function in patients with COVID-19.
Abstract: The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat to global public health. The highly infectious SARS-CoV-2 virus primarily attacks pulmonary tissues and impairs gas exchange leading to acute respiratory distress syndrome (ARDS) and systemic hypoxia. The current pharmacotherapies for COVID-19 largely rely on supportive and anti-thrombi treatment and the repurposing of antimalarial and antiviral drugs such as hydroxychloroquine and remdesivir. For a better mechanistic understanding of COVID-19, our present review focuses on its primary pathophysiologic features: hypoxia and cytokine storm, which are a prelude to multiple organ failure and lethality. We discussed a possible link between the activation of hypoxia inducible factor 1α (HIF-1α) and cell entry of SARS-CoV-2, since HIF-1α is shown to suppress the angiotensin-converting enzyme 2 (ACE2) receptor and transmembrane protease serine 2 (TMPRSS2) and upregulate disintegrin and metalloproteinase domain-containing protein 17 (ADAM17). In addition, the protein targets of HIF-1α are involved with the activation of pro-inflammatory cytokine expression and the subsequent inflammatory process. Furthermore, we hypothesized a potential utility of so-called "hypoxic conditioning" to activate HIF-1α-induced cytoprotective signaling for reduction of illness severity and improvement of vital organ function in patients with COVID-19. Taken together, we would propose further investigations into the hypoxia-related molecular mechanisms, from which novel targeted therapies can be developed for the improved management of COVID-19.

130 citations


Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2296 moreInstitutions (171)
TL;DR: In this article, a measurement of the mass of the Higgs boson in the diphoton decay channel is presented, based on 35.9 fb − 1 of proton-proton collision data collected during the 2016 LHC running period, with the CMS detector at a centre-of-mass energy of 13TeV.

126 citations


Journal ArticleDOI
TL;DR: This review seeks to place the toxicity of DMSO in context of its effectiveness, and considers means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.
Abstract: Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.

101 citations


Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2292 moreInstitutions (165)
TL;DR: The standard model (SM) production of four top quarks in proton-proton collisions is studied by the CMS Collaboration, with limits set on the production of a heavy scalar or pseudoscalar boson in Type-II two-Higgs-doublet and simplified dark matter models.
Abstract: The standard model (SM) production of four top quarks ($\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $) in proton–proton collisions is studied by the CMS Collaboration. The data sample, collected during the 2016–2018 data taking of the LHC, corresponds to an integrated luminosity of 137$\,\text {fb}^{-1}$ at a center-of-mass energy of 13$\,\text {TeV}$. The events are required to contain two same-sign charged leptons (electrons or muons) or at least three leptons, and jets. The observed and expected significances for the $\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $ signal are respectively 2.6 and 2.7 standard deviations, and the $\text {t} {}{\overline{\text {t}}} \text {t} {}{\overline{\text {t}}} $ cross section is measured to be $12.6^{+5.8}_{-5.2}\,\text {fb} $. The results are used to constrain the Yukawa coupling of the top quark to the Higgs boson, $y_{\text {t}}$, yielding a limit of $|y_{\text {t}}/y_{\text {t}}^{\mathrm {SM}} | < 1.7$ at $95\%$ confidence level, where $y_{\text {t}}^{\mathrm {SM}}$ is the SM value of $y_{\text {t}}$. They are also used to constrain the oblique parameter of the Higgs boson in an effective field theory framework, $\hat{H}<0.12$. Limits are set on the production of a heavy scalar or pseudoscalar boson in Type-II two-Higgs-doublet and simplified dark matter models, with exclusion limits reaching 350–470$\,\text {GeV}$ and 350–550$\,\text {GeV}$ for scalar and pseudoscalar bosons, respectively. Upper bounds are also set on couplings of the top quark to new light particles.

97 citations


Journal ArticleDOI
Ashot Margaryan1, Ashot Margaryan2, Daniel Lawson3, Martin Sikora2, Fernando Racimo2, Simon Rasmussen2, Ida Moltke2, Lara M. Cassidy4, Emil Jørsboe2, Andres Ingason2, Andres Ingason5, Mikkel Winther Pedersen2, Thorfinn Sand Korneliussen6, Thorfinn Sand Korneliussen2, Helene Wilhelmson7, Magdalena M. Buś8, Peter de Barros Damgaard2, Rui Martiniano9, Gabriel Renaud10, Gabriel Renaud2, Claude Bhérer11, J. Víctor Moreno-Mayar2, Anna K. Fotakis2, Marie Allen8, Raili Allmäe12, Martyna Molak13, Enrico Cappellini2, Gabriele Scorrano2, Hugh McColl2, Alexandra P. Buzhilova14, Allison M. Fox, Anders Albrechtsen2, Berit Schütz, Birgitte Skar15, Caroline Arcini, Ceri Falys, Charlotte Hedenstierna Jonson8, Dariusz Błaszczyk16, Denis Pezhemsky14, Gordon Turner-Walker17, Hildur Gestsdóttir, Inge Lundstrøm2, Ingrid Gustin7, Ingrid Mainland18, Inna Potekhina19, Italo M. Muntoni, Jade Cheng2, Jesper Stenderup2, Jilong Ma2, Julie Gibson18, Jüri Peets12, Jörgen Gustafsson, Katrine Højholt Iversen2, Katrine Højholt Iversen10, Linzi Simpson4, Lisa Strand15, Louise Loe20, Maeve Sikora21, Marek Florek22, Maria Vretemark, Mark Redknap23, Monika Bajka, Tamara Pushkina14, Morten Søvsø, Natalia Grigoreva24, Tom Christensen, Ole Kastholm, Otto Uldum, Pasquale Favia25, Per Holck26, Sabine Sten8, Símun V. Arge, Sturla Ellingvåg2, Vayacheslav Moiseyev24, Wiesław Bogdanowicz13, Yvonne Magnusson, Ludovic Orlando27, Peter Pentz, Mads Dengsø Jessen, Anne Pedersen, Mark Collard28, Daniel G. Bradley4, Marie Louise Jørkov2, Jette Arneborg29, Niels Lynnerup2, Neil Price8, M. Thomas P. Gilbert15, M. Thomas P. Gilbert2, Morten E. Allentoft30, Morten E. Allentoft2, Jan Bill26, Søren M. Sindbæk31, Lotte Hedeager, Kristian Kristiansen32, Rasmus Nielsen33, Rasmus Nielsen2, Thomas Werge, Eske Willerslev 
16 Sep 2020-Nature
TL;DR: It is concluded that the Viking diaspora was characterized by substantial transregional engagement: distinct populations influenced the genomic makeup of different regions of Europe, and Scandinavia experienced increased contact with the rest of the continent.
Abstract: The maritime expansion of Scandinavian populations during the Viking Age (about ad 750–1050) was a far-flung transformation in world history1,2. Here we sequenced the genomes of 442 humans from archaeological sites across Europe and Greenland (to a median depth of about 1×) to understand the global influence of this expansion. We find the Viking period involved gene flow into Scandinavia from the south and east. We observe genetic structure within Scandinavia, with diversity hotspots in the south and restricted gene flow within Scandinavia. We find evidence for a major influx of Danish ancestry into England; a Swedish influx into the Baltic; and Norwegian influx into Ireland, Iceland and Greenland. Additionally, we see substantial ancestry from elsewhere in Europe entering Scandinavia during the Viking Age. Our ancient DNA analysis also revealed that a Viking expedition included close family members. By comparing with modern populations, we find that pigmentation-associated loci have undergone strong population differentiation during the past millennium, and trace positively selected loci—including the lactase-persistence allele of LCT and alleles of ANKA that are associated with the immune response—in detail. We conclude that the Viking diaspora was characterized by substantial transregional engagement: distinct populations influenced the genomic makeup of different regions of Europe, and Scandinavia experienced increased contact with the rest of the continent. Ancient DNA analyses reveal that Viking Age migrations from Scandinavia resulted in differential influxes of ancestry to different parts of Europe, and the increased presence of non-local ancestry within Scandinavia.

95 citations



Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2357 moreInstitutions (213)
TL;DR: In this article, a search for narrow and broad resonances with masses greater than 1.8 TeV decaying to a pair of jets is presented, and the results show that no significant evidence for the production of new particles is observed.
Abstract: A search for narrow and broad resonances with masses greater than 1.8 TeV decaying to a pair of jets is presented. The search uses proton-proton collision data at $ \sqrt{s} $ = 13 TeV collected at the LHC, corresponding to an integrated luminosity of 137 fb$^{−1}$. The background arising from standard model processes is predicted with the fit method used in previous publications and with a new method. The dijet invariant mass spectrum is well described by both data-driven methods, and no significant evidence for the production of new particles is observed. Model independent upper limits are reported on the production cross sections of narrow resonances, and broad resonances with widths up to 55% of the resonance mass. Limits are presented on the masses of narrow resonances from various models: string resonances, scalar diquarks, axigluons, colorons, excited quarks, color-octet scalars, W′ and Z′ bosons, Randall-Sundrum gravitons, and dark matter mediators. The limits on narrow resonances are improved by 200 to 800 GeV relative to those reported in previous CMS dijet resonance searches. The limits on dark matter mediators are presented as a function of the resonance mass and width, and on the associated coupling strength as a function of the mediator mass. These limits exclude at 95% confidence level a dark matter mediator with a mass of 1.8 TeV and width 1% of its mass or higher, up to one with a mass of 4.8 TeV and a width 45% of its mass or higher.[graphic not available: see fulltext]

91 citations


Journal ArticleDOI
01 Feb 2020-Carbon
TL;DR: In this paper, a review of phosphorus-containing carbon materials is presented, focusing on their preparation, properties and applications, and the preparation methods include carbonization of carbon precursors with phosphorus compounds, modification of already prepared carbons and deposition of carbon and phosphorus from the gas phase.

89 citations


Journal ArticleDOI
18 Feb 2020
TL;DR: The known SIR model for the dynamics of an epidemic, the known exact solution of the linear differential equations and statistical approach developed before for investigation of the children disease, which occurred in Chernivtsi (Ukraine) in 1988–1989 was used to predict the characteristics of the epidemic caused by coronavirus in mainland China.
Abstract: Background. The epidemic outbreak caused by coronavirus COVID-19 is of great interest to researches because of the high rate of the infection spread and the significant number of fatalities. A detailed scientific analysis of the phenomenon is yet to come, but the public is already interested in the questions of the epidemic duration, the expected number of patients and deaths. Long-time predictions require complicated mathematical models that need a lot of effort to identify and calculate unknown parameters. This article will present some preliminary estimates. Objective. Since the long-time data are available only for mainland China, we will try to predict the epidemic characteristics only in this area. We will estimate some of the epidemic characteristics and present the dependen­cies for victim numbers, infected and removed persons versus time. Methods. In this study we use the known SIR model for the dynamics of an epidemic, the known exact solution of the linear differential equations and statistical approach developed before for investigation of the children disease, which occurred in Chernivtsi (Ukraine) in 1988–1989. Results. The optimal values of the SIR model parameters were identified with the use of statistical approach. The numbers of infected, susceptible and removed persons versus time were predicted and compared with the new data obtained after February 10, 2020, when the calculations were completed. Conclusions. The simple mathematical model was used to predict the characteristics of the epidemic caused by coronavirus in mainland China. Unfortunately, the number of coronavirus victims is expected to be much higher than that predicted on February 10, 2020, since 12289 new cases (not previously included in official counts) have been added two days later. Further research should focus on updating the predictions with the use of up-to-date data and using more complicated mathematical models.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2325 moreInstitutions (168)
TL;DR: In this article, the authors describe the performance of the Level-1 trigger upgrade during the data taking period of 2016-2018, which implements pattern recognition and boosted decision tree regression techniques for muon reconstruction, including pileup subtraction for jets and energy sums, and incorporates pileupdependent isolation requirements for electrons and tau leptons.
Abstract: At the start of Run 2 in 2015, the LHC delivered proton-proton collisions at a center-of-mass energy of 13\TeV. During Run 2 (years 2015–2018) the LHC eventually reached a luminosity of 2.1× 1034 cm-2s-1, almost three times that reached during Run 1 (2009–2013) and a factor of two larger than the LHC design value, leading to events with up to a mean of about 50 simultaneous inelastic proton-proton collisions per bunch crossing (pileup). The CMS Level-1 trigger was upgraded prior to 2016 to improve the selection of physics events in the challenging conditions posed by the second run of the LHC. This paper describes the performance of the CMS Level-1 trigger upgrade during the data taking period of 2016–2018. The upgraded trigger implements pattern recognition and boosted decision tree regression techniques for muon reconstruction, includes pileup subtraction for jets and energy sums, and incorporates pileup-dependent isolation requirements for electrons and tau leptons. In addition, the new trigger calculates high-level quantities such as the invariant mass of pairs of reconstructed particles. The upgrade reduces the trigger rate from background processes and improves the trigger efficiency for a wide variety of physics signals.

Journal ArticleDOI
TL;DR: Criteria for a high-quality compound library design enabling efficient virtual navigation of chemical space, as well as rise and fall of concepts for its synthetic exploration (such as combinatorial chemistry, diversity-, biology-, lead-, or fragment-oriented syntheses, DNA-encoded libraries etc.) are critically surveyed.
Abstract: All pharmaceutical products contain organic molecules; the source may be a natural product or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry underpins both existing and upcoming pharmaceutical products. The reverse relationship has also affected organic synthesis, changing its landscape towards increasingly complex targets. This Review article sets out to give a concise appraisal of this symbiotic relationship between organic chemistry and drug discovery, along with a discussion of the design concepts and highlighting key milestones along the journey. In particular, criteria for a high-quality compound library design enabling efficient virtual navigation of chemical space, as well as rise and fall of concepts for its synthetic exploration (such as combinatorial chemistry; diversity-, biology-, lead-, or fragment-oriented syntheses; and DNA-encoded libraries) are critically surveyed.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2399 moreInstitutions (209)
TL;DR: In this article, a search for additional scalar (H) or pseudoscalar (A) Higgs bosons decaying to a top quark pair in proton-proton collisions at a center-of-mass energy of 13 TeV is presented.
Abstract: A search is presented for additional scalar (H) or pseudoscalar (A) Higgs bosons decaying to a top quark pair in proton-proton collisions at a center-of-mass energy of 13 TeV. The data set analyzed corresponds to an integrated luminosity of 35.9 fb−1 collected by the CMS experiment at the LHC. Final states with one or two charged leptons are considered. The invariant mass of the reconstructed top quark pair system and variables that are sensitive to the spin of the particles decaying into the top quark pair are used to search for signatures of the H or A bosons. The interference with the standard model top quark pair background is taken into account. A moderate signal-like deviation compatible with an A boson with a mass of 400 GeV is observed with a global significance of 1.9 standard deviations. New stringent constraints are reported on the strength of the coupling of the hypothetical bosons to the top quark, with the mass of the bosons ranging from 400 to 750 GeV and their total relative width from 0.5 to 25%. The results of the search are also interpreted in a minimal supersymmetric standard model scenario. Values of mA from 400 to 700 GeV are probed, and a region with values of tan β below 1.0 to 1.5, depending on mA, is excluded at 95% confidence level.

Journal ArticleDOI
TL;DR: It is shown that the energy losses in coupled heterogeneous Newtonian oscillators can significantly alter power grid dynamics by introducing solitary states in the network.
Abstract: The stability of synchronised networked systems is a multi-faceted challenge for many natural and technological fields, from cardiac and neuronal tissue pacemakers to power grids. For these, the ongoing transition to distributed renewable energy sources leads to a proliferation of dynamical actors. The desynchronisation of a few or even one of those would likely result in a substantial blackout. Thus the dynamical stability of the synchronous state has become a leading topic in power grid research. Here we uncover that, when taking into account physical losses in the network, the back-reaction of the network induces new exotic solitary states in the individual actors and the stability characteristics of the synchronous state are dramatically altered. These effects will have to be explicitly taken into account in the design of future power grids. We expect the results presented here to transfer to other systems of coupled heterogeneous Newtonian oscillators.

Journal ArticleDOI
TL;DR: The principles and main purposes of using multienzyme systems in electrochemical biosensors, along with principles of function, advantages, disadvantages and practical use for real sample analyses in various application areas are analyzed.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2361 moreInstitutions (173)
TL;DR: In this paper, a search for long-lived charged particles that decay within the volume of the silicon tracker of the LHC experiment is presented for events with this "disappearing track" signature.

Journal ArticleDOI
TL;DR: This work identifies eastern Europe as the most probable ancestral source region for the Chagyrskaya toolmakers, supported by DNA results linking the Neanderthal remains with populations in northern Croatia and the northern Caucasus, and providing a rare example of a long-distance, intercontinental population movement associated with a distinctive Paleolithic toolkit.
Abstract: Neanderthals were once widespread across Europe and western Asia. They also penetrated into the Altai Mountains of southern Siberia, but the geographical origin of these populations and the timing of their dispersal have remained elusive. Here we describe an archaeological assemblage from Chagyrskaya Cave, situated in the Altai foothills, where around 90,000 Middle Paleolithic artifacts and 74 Neanderthal remains have been recovered from deposits dating to between 59 and 49 thousand years ago (age range at 95.4% probability). Environmental reconstructions suggest that the Chagyrskaya hominins were adapted to the dry steppe and hunted bison. Their distinctive toolkit closely resembles Micoquian assemblages from central and eastern Europe, including the northern Caucasus, more than 3,000 kilometers to the west of Chagyrskaya Cave. At other Altai sites, evidence of earlier Neanderthal populations lacking associated Micoquian-like artifacts implies two or more Neanderthal incursions into this region. We identify eastern Europe as the most probable ancestral source region for the Chagyrskaya toolmakers, supported by DNA results linking the Neanderthal remains with populations in northern Croatia and the northern Caucasus, and providing a rare example of a long-distance, intercontinental population movement associated with a distinctive Paleolithic toolkit.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2378 moreInstitutions (212)
TL;DR: In this paper, a search for charged Higgs bosons decaying into a top and a bottom quark in the all-jet final state is presented, using LHC proton-proton collision data recorded with the CMS detector in 2016 at 13 TeV, corresponding to an integrated luminosity of 35.9 fb$−1.
Abstract: A search for charged Higgs bosons (H$^{±}$) decaying into a top and a bottom quark in the all-jet final state is presented. The analysis uses LHC proton-proton collision data recorded with the CMS detector in 2016 at $ \sqrt{s} $ = 13 TeV, corresponding to an integrated luminosity of 35.9 fb$^{−1}$. No significant excess is observed above the expected background. Model-independent upper limits at 95% confidence level are set on the product of the H$^{±}$ production cross section and branching fraction in two scenarios. For production in association with a top quark, limits of 21.3 to 0.007 pb are obtained for H$^{±}$ masses in the range of 0.2 to 3 TeV. Combining this with a search in leptonic final states results in improved limits of 9.25 to 0.005 pb. The complementary s-channel production of an H$^{±}$ is investigated in the mass range of 0.8 to 3 TeV and the corresponding upper limits are 4.5 to 0.023 pb. These results are interpreted using different minimal supersymmetric extensions of the standard model.[graphic not available: see fulltext]

Journal ArticleDOI
Shreyasi Acharya1, Dagmar Adamová2, Alexander Adler3, Jonatan Adolfsson4  +1017 moreInstitutions (103)
TL;DR: The measured spin alignment is unexpectedly large but qualitatively consistent with the expectation from models which attribute it to a polarization of quarks in the presence of angular momentum in heavy-ion collisions and a subsequent hadronization by the process of recombination.
Abstract: The first evidence of spin alignment of vector mesons (K0 and ϕ) in heavy-ion collisions at the Large Hadron Collider (LHC) is reported. The spin density matrix element ρ00 is measured at midrapidity (|y| < 0.5) in Pb-Pb collisions at a center-of-mass energy (√sNN) of 2.76 TeV with the ALICE detector. ρ00 values are found to be less than 1=3 (1=3 implies no spin alignment) at low transverse momentum (pT < 2 GeV/c) for K0 and ϕ at a level of 3σ and 2σ, respectively. No significant spin alignment is observed for the K^0_S meson (spin = 0) in Pb-Pb collisions and for the vector mesons in pp collisions. The measured spin alignment is unexpectedly large but qualitatively consistent with the expectation from models which attribute it to a polarization of quarks in the presence of angular momentum in heavy-ion collisions and a subsequent hadronization by the process of recombination.

Posted ContentDOI
13 Feb 2020-medRxiv
TL;DR: A simple mathematical model was used to predict the characteristics of the epidemic caused by coronavirus 2019-nCoV in mainland China and the optimal values of the SIR model parameters were identified with the use of statistical approach.
Abstract: Background The epidemic outbreak cased by coronavirus 2019-nCoV is of great interest to researches because of the high rate of spread of the infection and the significant number of fatalities. A detailed scientific analysis of the phenomenon is yet to come, but the public is already interested in the questions of the duration of the epidemic, the expected number of patients and deaths. For long time predictions, the complicated mathematical models are necessary which need many efforts for unknown parameters identification and calculations. In this article, some preliminary estimates will be presented. Objective Since the reliable long time data are available only for mainland China, we will try to predict the epidemic characteristics only in this area. We will estimate some of the epidemic characteristics and present the most reliable dependences for victim numbers, infected and removed persons versus time. Methods In this study we use the known SIR model for the dynamics of an epidemic, the known exact solution of the linear equations and statistical approach developed before for investigation of the children disease, which occurred in Chernivtsi (Ukraine) in 1988-1989. Results The optimal values of the SIR model parameters were identified with the use of statistical approach. The numbers of infected, susceptible and removed persons versus time were predicted. Conclusions Simple mathematical model was used to predict the characteristics of the epidemic caused by coronavirus 2019-nCoV in mainland China. The further research should focus on updating the predictions with the use of fresh data and using more complicated mathematical models.

Journal ArticleDOI
TL;DR: In this article, a search for direct top-squark pair production is presented based on proton-proton collision data at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the LHC during 2016, 2017, and 2018, corresponding to an integrated luminosity of 137 fb−1.
Abstract: A search for direct top squark pair production is presented. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the LHC during 2016, 2017, and 2018, corresponding to an integrated luminosity of 137 fb−1. The search is carried out using events with a single isolated electron or muon, multiple jets, and large transverse momentum imbalance. The observed data are consistent with the expectations from standard model processes. Exclusions are set in the context of simplified top squark pair production models. Depending on the model, exclusion limits at 95% confidence level for top squark masses up to 1.2 TeV are set for a massless lightest supersymmetric particle, assumed to be the neutralino. For models with top squark masses of 1 TeV, neutralino masses up to 600 GeV are excluded.

Journal ArticleDOI
TL;DR: In this article, the authors present new developments in the stellar-remnant formation and related schemes of the current N -body evolution program NBODY7 and demonstrate that the newly implemented stellar-wind and remnant-formation schemes in the NBODY-7 code, such as the "rapid" and "delayed" supernova (SN) schemes along with an implementation of pulsational-pairinstability and pair-instability supernova, now produce neutron star (NS) and BH masses that agree nearly perfectly, over large ranges of zero-age-main-
Abstract: Context. As a result of their formation via massive single and binary stellar evolution, the masses of stellar-remnant black holes (BH) are subjects of great interest in this era of gravitational-wave detection from binary black hole (BBH) and binary neutron star merger events.Aims. In this work, we present new developments in the stellar-remnant formation and related schemes of the current N -body evolution program NBODY7. We demonstrate that the newly implemented stellar-wind and remnant-formation schemes in the stellar-evolutionary sector or BSE of the NBODY7 code, such as the “rapid” and the “delayed” supernova (SN) schemes along with an implementation of pulsational-pair-instability and pair-instability supernova (PPSN/PSN), now produce neutron star (NS) and BH masses that agree nearly perfectly, over large ranges of zero-age-main-sequence (ZAMS) mass and metallicity, with those from the widely recognised StarTrack population-synthesis program. We also demonstrate the new, recipe-based implementations of various widely debated mechanisms of natal kicks on NSs and BHs, such as “convection-asymmetry-driven”, “collapse-asymmetry-driven”, and “neutrino-emission-driven” kicks, in addition to a fully consistent implementation of the standard, fallback-dependent, momentum-conserving natal kick.Methods. All the above newly implemented schemes are also shared with the standalone versions of SSE and BSE. All these demonstrations are performed with both the updated standalone BSE and the updated NBODY7/BSE.Results. When convolved with stellar and primordial-binary populations as observed in young massive clusters, such remnant-formation and natal-kick mechanisms crucially determine the accumulated number, mass, and mass distribution of the BHs retained in young massive, open, and globular clusters (GCs); these BHs would eventually become available for long-term dynamical processing.Conclusions. Among other conclusions, we find that although the newer, delayed SN remnant formation model gives birth to the largest number (mass) of BHs, the older remnant-formation schemes cause the largest number (mass) of BHs to survive in clusters, when incorporating SN material fallback onto the BHs. The SN material fallback also causes the convection-asymmetry-driven SN kick to effectively retain similar numbers and masses of BHs in clusters as for the standard, momentum-conserving kick. The collapse-asymmetry-driven SN kick would cause nearly all BHs to be retained in clusters irrespective of their mass, remnant-formation model, and metallicity, whereas the inference of a large population of BHs in GCs would potentially rule out the neutrino-driven SN kick mechanism. Pre-SN mergers of massive primordial binaries would potentially cause BH masses to deviate from the theoretical, single-star ZAMS to mass-remnant mass relation unless a substantial of the total merging stellar mass of up to ≈40% is lost during a merger process. In particular, such mergers, at low metallicities, have the potential to produce low-spinning BHs within the PSN mass gap that can be retained in a stellar cluster and be available for subsequent dynamical interactions. As recent studies indicate, the new remnant-formation modelling reassures us that young massive and open clusters would potentially contribute to the dynamical BBH merger detection rate to a similar extent as their more massive GC counterparts.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2285 moreInstitutions (170)
TL;DR: In this article, the performance of these techniques for jet and missing transverse momentum reconstruction, as well as muon isolation is surveyed. But the authors focus on the identification of pileup jets, the jet energy, mass, and angular resolution, missing transversal momentum resolution, and Muon isolation when using pileup per particle identification.
Abstract: With increasing instantaneous luminosity at the LHC come additional reconstruction challenges. At high luminosity, many collisions occur simultaneously within one proton-proton bunch crossing. The isolation of an interesting collision from the additional "pileup" collisions is needed for effective physics performance. In the CMS Collaboration, several techniques capable of mitigating the impact of these pileup collisions have been developed. Such methods include charged-hadron subtraction, pileup jet identification, isospin-based neutral particle "δβ" correction, and, most recently, pileup per particle identification. This paper surveys the performance of these techniques for jet and missing transverse momentum reconstruction, as well as muon isolation. The analysis makes use of data corresponding to 35.9 fb−1 collected with the CMS experiment in 2016 at a center-of-mass energy of 13 TeV. The performance of each algorithm is discussed for up to 70 simultaneous collisions per bunch crossing. Significant improvements are found in the identification of pileup jets, the jet energy, mass, and angular resolution, missing transverse momentum resolution, and muon isolation when using pileup per particle identification.

Journal ArticleDOI
Shreyasi Acharya1, Dagmar Adamová2, Alexander Adler3, Jonatan Adolfsson4  +1019 moreInstitutions (109)
TL;DR: These observations challenge some recent theoretical calculations, which predicted a negative and an order of magnitude smaller value of dΔv_{1}/dη for both light flavor and charmed hadrons.
Abstract: The first measurement at the LHC of charge-dependent directed flow (v1) relative to the spectator plane is presented for Pb-Pb collisions at √sNN p = 5.02 TeV. Results are reported for charged hadrons and D0 mesons for the transverse momentum intervals pT > 0.2 GeV=c and 3 < pT < 6 GeV=c in the 5%–40% and 10%–40% centrality classes, respectively. The difference between the positively and negatively charged hadron v1 has a positive slope as a function of pseudorapidity η, dΔv1=dη = [1.68 ± 0.49(stat) x 0.41(syst) × 10^−4. The same measurement for D^0 and D¯ ^0 mesons yields a positive value dΔv1/dη = [4.9 ± 1.7(stat) ± 0.6(syst) × 10^−1, which is about 3 orders of magnitude larger than the one of the charged hadrons. These measurements can provide new insights into the effects of the strong electromagnetic field and the initial tilt of matter created in noncentral heavy ion collisions on th e dynamics of light (u, d, and s) and heavy (c) quarks. The large difference between the observed Δv1 of charged hadrons and D0 mesons may reflect different sensitivity of the charm and light quarks to the early time dynamics of a heavy ion collision. These observations challenge some recent theoretical calculations, which predicted a negative and an order of magnitude smaller value of dΔv1=dη for both light flavor and charmed hadrons.

Journal ArticleDOI
TL;DR: In this paper, a non-local chiral symmetry breaking effect is introduced, which is essentially nonlocal and resembles itself even in static spin textures living in curvilinear magnetic nanoshells.
Abstract: The concept of curvature and chirality in space and time are foundational for the understanding of the organic life and formation of matter in the Universe. Chiral interactions but also curvature effects are tacitly accepted to be local. A prototypical condensed matter example is a local spin-orbit- or curvature-induced Rashba or Dzyaloshinskii-Moriya interactions. Here, we introduce a chiral effect, which is essentially nonlocal and resembles itself even in static spin textures living in curvilinear magnetic nanoshells. Its physical origin is the nonlocal magnetostatic interaction. To identify this interaction, we put forth a self-consistent micromagnetic framework of curvilinear magnetism. Understanding of the nonlocal physics of curved magnetic shells requires a curvature-induced geometrical charge, which couples the magnetic sub-system with the curvilinear geometry. The chiral interaction brings about a nonlocal chiral symmetry breaking effect: it introduces handedness in an intrinsically achiral material and enables the design of magnetolectric and ferrotoroidic responses. Curvature effects in a magnetic system are usually described by treating local and non-local interactions separately. Here, the authors develop a theory of curvilinear micromagnetism and report a non-local chiral interaction which is absent in flat systems.

Journal ArticleDOI
TL;DR: In this paper, the authors demonstrate TFETs based on BP/InSe heterojunctions with diverse electrical transport characteristics: forward rectifying, Zener-tunneling and backward rectifying characteristics are realized in BP/INSe junctions with different thickness of the BP layer or by electrostatic gating of the junction.
Abstract: Atomically thin layers of van der Waals (vdW) crystals offer an ideal material platform to realize tunnel field effect transistors (TFETs) that exploit the tunneling of charge carriers across the forbidden gap of a vdW heterojunction. This type of device requires a precise energy band alignment of the different layers of the junction to optimize the tunnel current. Amongst two-dimensional (2D) vdW materials, black phosphorus (BP) and indium selenide (InSe) have a Brillouin zone-centered conduction and valence bands, and a type II band offset, both ideally suited for band-to-band tunneling. Here, we demonstrate TFETs based on BP/InSe heterojunctions with diverse electrical transport characteristics: forward rectifying, Zener-tunneling and backward rectifying characteristics are realized in BP/InSe junctions with different thickness of the BP layer or by electrostatic gating of the junction. Electrostatic gating yields a large on/off current ratio of up to 108 and negative differential resistance at low applied voltages (V ~ 0.2V). These findings illustrate versatile functionalities of TFETs based on BP and InSe, offering opportunities for applications of these 2D materials beyond the device architectures reported in the current literature.

Journal ArticleDOI
TL;DR: From systematic imaging experiments, it is inferred the formation of a partially polarized antiferroelectric state, with inclusions of structurally distinct ferrielectric domains enclosed by the corresponding phase boundaries, which may lead to rational strategies for incorporation of ferroic functionality into van der Waals heterostructures with stronger resilience toward detrimental size-effects.
Abstract: Polar van der Waals chalcogenophosphates exhibit unique properties, such as negative electrostriction and multi-well ferrielectricity, and enable combining dielectric and 2D electronic materials. Using low temperature piezoresponse force microscopy, we revealed coexistence of piezoelectric and non-piezoelectric phases in CuInP2Se6, forming unusual domain walls with enhanced piezoelectric response. From systematic imaging experiments we have inferred the formation of a partially polarized antiferroelectric state, with inclusions of structurally distinct ferrielectric domains enclosed by the corresponding phase boundaries. The assignment is strongly supported by optical spectroscopies and density-functional-theory calculations. Enhanced piezoresponse at the ferrielectric/antiferroelectric phase boundary and the ability to manipulate this entity with electric field on the nanoscale expand the existing phenomenology of functional domain walls. At the same time, phase-coexistence in chalcogenophosphates may lead to rational strategies for incorporation of ferroic functionality into van der Waals heterostructures, with stronger resilience toward detrimental size-effects. Domain walls in van der Waals layered ferrielectric CuInP2Se6 exhibit piezoelectric response. This striking departure from traditional ferroelectric behavior is ascribed to a partially polarized antiferroelectric state, where the domain wall separates coexisting regions of ferrielectric and antiferroelectric phases.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2282 moreInstitutions (164)
TL;DR: In this paper, two related searches for phenomena beyond the standard model (BSM) are performed using events with hadronic jets and significant transverse momentum imbalance, based on a sample of proton-proton collisions at a center-of-mass energy of $13,\text {Te}\text {V} $, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 137$
Abstract: Two related searches for phenomena beyond the standard model (BSM) are performed using events with hadronic jets and significant transverse momentum imbalance. The results are based on a sample of proton–proton collisions at a center-of-mass energy of $13\,\text {Te}\text {V} $, collected by the CMS experiment at the LHC in 2016–2018 and corresponding to an integrated luminosity of 137$\,\text {fb}^{-1}$. The first search is inclusive, based on signal regions defined by the hadronic energy in the event, the jet multiplicity, the number of jets identified as originating from bottom quarks, and the value of the kinematic variable $M_{\mathrm {T2}}$ for events with at least two jets. For events with exactly one jet, the transverse momentum of the jet is used instead. The second search looks in addition for disappearing tracks produced by BSM long-lived charged particles that decay within the volume of the tracking detector. No excess event yield is observed above the predicted standard model background. This is used to constrain a range of BSM models that predict the following: the pair production of gluinos and squarks in the context of supersymmetry models conserving R-parity, with or without intermediate long-lived charginos produced in the decay chain, the resonant production of a colored scalar state decaying to a massive Dirac fermion and a quark, or the pair production of scalar and vector leptoquarks each decaying to a neutrino and a top, bottom, or light-flavor quark. In most of the cases, the results obtained are the most stringent constraints to date.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2270 moreInstitutions (155)
TL;DR: The search is presented for a narrow resonance decaying to a pair of oppositely charged muons using sqrt[s]=13 TeV proton-proton collision data recorded at the LHC, setting the most stringent constraints to date on a dark photon in the ∼30-75 and 110-200 GeV mass ranges.
Abstract: A search is presented for a narrow resonance decaying to a pair of oppositely charged muons using s=13 TeV proton-proton collision data recorded at the LHC. In the 45–75 and 110–200 GeV resonance mass ranges, the search is based on conventional triggering and event reconstruction techniques. In the 11.5–45 GeV mass range, the search uses data collected with dimuon triggers with low transverse momentum thresholds, recorded at high rate by storing a reduced amount of trigger-level information. The data correspond to integrated luminosities of 137 and 96.6 fb-1 for conventional and high-rate triggering, respectively. No significant resonant peaks are observed in the probed mass ranges. The search sets the most stringent constraints to date on a dark photon in the ∼30–75 and 110–200 GeV mass ranges.