Institution
Somerset Hospital
Healthcare•Cape Town, South Africa•
About: Somerset Hospital is a healthcare organization based out in Cape Town, South Africa. It is known for research contribution in the topics: Population & Health care. The organization has 455 authors who have published 468 publications receiving 13034 citations.
Topics: Population, Health care, Fludarabine, Pregnancy, Cancer
Papers published on a yearly basis
Papers
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TL;DR: Cohort, cross sectional, and case-control studies are collectively referred to as observational studies, and seek to identify possible predictors of outcome and are useful for studying rare diseases or outcomes.
Abstract: Cohort, cross sectional, and case-control studies are collectively referred to as observational studies. Often these studies are the only practicable method of studying various problems, for example, studies of aetiology, instances where a randomised controlled trial might be unethical, or if the condition to be studied is rare. Cohort studies are used to study incidence, causes, and prognosis. Because they measure events in chronological order they can be used to distinguish between cause and effect. Cross sectional studies are used to determine prevalence. They are relatively quick and easy but do not permit distinction between cause and effect. Case controlled studies compare groups retrospectively. They seek to identify possible predictors of outcome and are useful for studying rare diseases or outcomes. They are often used to generate hypotheses that can then be studied via prospective cohort or other studies.
1,319 citations
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TL;DR: Fludarabine provided an effective and well-tolerated therapy for patients with advanced CLL, which compared favourably with CAP as one of the most effective standard regimens.
460 citations
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TL;DR: In this article, a review of 65 patients who had undergone arthroscopic treatment for osteochondral lesions of the talus was carried out for a mean of 3.5 years.
Abstract: We reviewed, retrospectively, 65 patients who had undergone arthroscopic treatment for osteochondral lesions of the talus. The 46 men and 19 women with a mean age at operation of 34.25 years, were followed up for a mean of 3.5 years. The medial aspect was affected in 45 patients and the lateral aspect in 20. All the lateral lesions and 35 (75%) of the medial lesions were traumatic in origin. Medial lesions presented later than lateral lesions (3 v 1.5 years) and had a much greater incidence of cystic change (46% v 8%). At follow-up, 34 patients had achieved a good result, and 17 and 14 fair and poor results, respectively. Of the 14 poor results, 13 involved medial lesions. Cystic lesions had a poor outcome in 53% of patients. Excision and curettage led to better results than excision and drilling of the base. Further arthroscopic surgery for patients with a poor result was disappointing. There was no association between outcome and the patient's age.
403 citations
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TL;DR: Short‐term outcomes of laparoscopic and open resection of colorectal cancer within a programme of perioperative care optimized within an enhanced recovery programme are compared.
Abstract: Background:
Laparoscopic resection of colorectal cancer may improve short-term outcome without compromising long-term survival or disease control. Recent evidence suggests that the difference between laparoscopic and open surgery may be less significant when perioperative care is optimized within an enhanced recovery programme. This study compared short-term outcomes of laparoscopic and open resection of colorectal cancer within such a programme.
Methods:
Between January 2002 and March 2004, 62 patients were randomized on a 2 : 1 basis to receive laparoscopic (n = 43) or open (n = 19) surgery. All were entered into an enhanced recovery programme. Length of hospital stay was the primary endpoint. Secondary outcomes of functional recovery, quality of life and cost were assessed for 3 months after surgery.
Results:
Demographics of the two groups were similar. Length of hospital stay after laparoscopic resection was 32 (95 per cent confidence interval (c.i.) 7 to 51) per cent shorter than for open resection (P = 0·018). Combined hospital, convalescent and readmission stay was 37 (95 per cent c.i. 10 to 56) per cent shorter (P = 0·012). The relative risk of complications, quality of life results and cost data were similar in the two groups.
Conclusion:
Despite perioperative optimization of open surgery for colorectal cancer, short-term outcomes were better following laparoscopic surgery. There was no deterioration in quality of life or increased cost associated with the laparoscopic approach. Copyright © 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
360 citations
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TL;DR: Nonsteroidal anti-inflammatory drugs and other medications were significant risk factors in subjects with functional constipation and outlet delay combined and among these subjects, there appear to be symptom subgroups that can be identified.
231 citations
Authors
Showing all 455 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peter Collins | 67 | 230 | 18069 |
John S. Terblanche | 64 | 373 | 14855 |
Jeremy W. Tomlinson | 58 | 211 | 12878 |
H S Schaaf | 49 | 192 | 8150 |
Jonathan Rees | 44 | 173 | 6069 |
Simon Rule | 42 | 255 | 8169 |
Heather Skirton | 39 | 198 | 4424 |
Robert Andrews | 36 | 103 | 12312 |
Richard Welbourn | 35 | 115 | 4169 |
M. D. Smith | 33 | 46 | 3001 |
Donald A. Hudson | 28 | 97 | 2717 |
Dimitrios Siassakos | 28 | 127 | 3189 |
Joanna F. Crofts | 26 | 59 | 2797 |
Kathryn Chu | 26 | 58 | 2000 |
Stephen A. Johnson | 26 | 62 | 2268 |