Institution
VU University Medical Center
Healthcare•Amsterdam, Noord-Holland, Netherlands•
About: VU University Medical Center is a healthcare organization based out in Amsterdam, Noord-Holland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 10882 authors who have published 22907 publications receiving 1156378 citations. The organization is also known as: VUmc.
Topics: Population, Randomized controlled trial, Cancer, Anxiety, Dementia
Papers published on a yearly basis
Papers
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University of Bologna1, National and Kapodistrian University of Athens2, Columbia University Medical Center3, VU University Medical Center4, University Hospital Heidelberg5, University of Freiburg6, Carolinas Healthcare System7, University of Navarra8, Mayo Clinic9, Harvard University10, Instituto Português de Oncologia Francisco Gentil11, Odense University Hospital12, University of Texas MD Anderson Cancer Center13, University Health System14, Emory University15, Cedars-Sinai Medical Center16
TL;DR: Based on the ability of 18F-FDG PET/CT to distinguish between metabolically active and inactive disease, this technique is now the preferred functional imaging modality to evaluate and to monitor the effect of therapy on myeloma-cell metabolism.
Abstract: The International Myeloma Working Group consensus aimed to provide recommendations for the optimal use of 18fluorodeoxyglucose (18F-FDG) PET/CT in patients with multiple myeloma and other plasma cell disorders, including smouldering multiple myeloma and solitary plasmacytoma. 18F-FDG PET/CT can be considered a valuable tool for the work-up of patients with both newly diagnosed and relapsed or refractory multiple myeloma because it assesses bone damage with relatively high sensitivity and specificity, and detects extramedullary sites of proliferating clonal plasma cells while providing important prognostic information. The use of 18F-FDG PET/CT is mandatory to confirm a suspected diagnosis of solitary plasmacytoma, provided that whole-body MRI is unable to be performed, and to distinguish between smouldering and active multiple myeloma, if whole-body X-ray (WBXR) is negative and whole-body MRI is unavailable. Based on the ability of 18F-FDG PET/CT to distinguish between metabolically active and inactive disease, this technique is now the preferred functional imaging modality to evaluate and to monitor the effect of therapy on myeloma-cell metabolism. Changes in FDG avidity can provide an earlier evaluation of response to therapy compared to MRI scans, and can predict outcomes, particularly for patients who are eligible to receive autologous stem-cell transplantation. 18F-FDG PET/CT can be coupled with sensitive bone marrow-based techniques to detect minimal residual disease (MRD) inside and outside the bone marrow, helping to identify those patients who are defined as having imaging MRD negativity.
338 citations
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TL;DR: In this article, the authors investigated 3-year survival following a randomized controlled trial comparing minimally invasive with open esophagectomy in patients with esophageal cancer, and found that the latter had faster postoperative recovery.
Abstract: Objective:The aim of this study was to investigate 3-year survival following a randomized controlled trial comparing minimally invasive with open esophagectomy in patients with esophageal cancer.Background:Research on minimally invasive esophagectomy (MIE) has shown faster postoperative recovery and
338 citations
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TL;DR: A new Dutch speech-in-noise test was developed, made fully automatic, controlled by a computer, and can be done by telephone, which measures the speech reception threshold using an adaptive procedure, and showed no significant influence of telephone type or listening environment.
Abstract: To meet the need for an objective self-test for hearing screening, a new Dutch speech-in-noise test was developed. Digit triplets were used as speech material. The test was made fully automatic, was controlled by a computer, and can be done by telephone. It measures the speech reception threshold (triplet SRTn) using an adaptive procedure, in about 3 min. Our experiments showed no significant influence of telephone type or listening environment. Measurement errors were within 1 dB, which makes the test accurate. In additional experiments with hearing-impaired subjects (76 ears of 38 listeners), the new test was compared to the existing sentence SRTn test of Plomp and Mimpen, which is considered to be the standard. The correlation between both SRTns was 0.866. As expected, correlations between the triplet SRTn test by telephone and average pure-tone thresholds are somewhat lower: 0.732 for PTA0.5, 1, 2, and 0.770 for PTA0.5, 1, 2,4. When proper SRTn values were chosen for distinguishing between normal-hear...
337 citations
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Pompeu Fabra University1, Florey Institute of Neuroscience and Mental Health2, Hoffmann-La Roche3, Takeda Pharmaceutical Company4, Genentech5, Lou Ruvo Brain Institute6, Washington University in St. Louis7, Mayo Clinic8, Biogen Idec9, University of North Texas Health Science Center10, VU University Medical Center11, University of Pennsylvania12, Lundbeck13, University of Gothenburg14
TL;DR: Some of the pathological mechanisms implicated in the sporadic AD are summarized and the data for several established and novel fluid biomarkers associated with each mechanism are highlighted.
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is predicted to increase; however, there are no disease-modifying therapies currently available and none have been successful in late-stage clinical trials. Fluid biomarkers measured in cerebrospinal fluid (CSF) or blood hold promise for enabling more effective drug development and establishing a more personalized medicine approach for AD diagnosis and treatment. Biomarkers used in drug development programmes should be qualified for a specific context of use (COU). These COUs include, but are not limited to, subject/patient selection, assessment of disease state and/or prognosis, assessment of mechanism of action, dose optimization, drug response monitoring, efficacy maximization, and toxicity/adverse reactions identification and minimization. The core AD CSF biomarkers Aβ42, t-tau, and p-tau are recognized by research guidelines for their diagnostic utility and are being considered for qualification for subject selection in clinical trials. However, there is a need to better understand their potential for other COUs, as well as identify additional fluid biomarkers reflecting other aspects of AD pathophysiology. Several novel fluid biomarkers have been proposed, but their role in AD pathology and their use as AD biomarkers have yet to be validated. In this review, we summarize some of the pathological mechanisms implicated in the sporadic AD and highlight the data for several established and novel fluid biomarkers (including BACE1, TREM2, YKL-40, IP-10, neurogranin, SNAP-25, synaptotagmin, α-synuclein, TDP-43, ferritin, VILIP-1, and NF-L) associated with each mechanism. We discuss the potential COUs for each biomarker.
337 citations
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TL;DR: It is shown that women have higher prevalence rates of musculoskeletal pain in most anatomic pain sites, no matter the duration of musculean pain.
Abstract: OBJECTIVES: Many studies report a higher prevalence of musculoskeletal pain in women than in men This paper presents an overview of sex differences in musculoskeletal pain with specific attention for: different parameters for duration of musculoskeletal pain (ie, 1-y period prevalence, point prevalence, prevalence of chronic pain, and prevalence of persistent chronic pain); and (2) different anatomic pain sites METHODS: For the analyses, data from 2 general population-based prospective surveys (Dutch population-based Musculoskeletal Complaints and Consequences Cohort study and Monitoring Project on Risk Factors for Chronic Diseases-study) were used The study population consisted of persons aged 25 to 64 years living in the Netherlands Data on self-reported pain complaints were assessed by written questionnaires RESULTS: The results of this study showed that prevalence rates of musculoskeletal pain were higher for women than for men in the Dutch general population aged 25 to 64 years on the basis of 2 population-based surveys For musculoskeletal pain in any location, 39% of men and 45% of women reported chronic complaints Highest female predominance was found for the hip and wrist/hand, whereas lowest and not statistically significant sex differences were found for the lower back and knee All duration parameters of musculoskeletal pain showed a female predominance of musculoskeletal pain (1-y period prevalence, point prevalence, prevalence of chronic pain, and prevalence of persistent chronic pain) In those with persistent chronic pain, women tended to report higher severity scores DISCUSSION: The present study shows that women have higher prevalence rates of musculoskeletal pain in most anatomic pain sites, no matter the duration of musculoskeletal pain Future research should focus on explaining these sex differences with the ultimate goal to develop better prevention and management strategies for musculoskeletal pain in both men and women
336 citations
Authors
Showing all 10902 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Michael John Owen | 160 | 1110 | 135795 |
Lex M. Bouter | 158 | 767 | 103034 |
Frederik Barkhof | 154 | 1449 | 104982 |
Ichiro Kawachi | 149 | 1216 | 90282 |
Walter Paulus | 149 | 809 | 86252 |
Philip Scheltens | 140 | 1175 | 107312 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Pim Cuijpers | 136 | 982 | 69370 |
Jeffrey S. Flier | 131 | 314 | 78430 |
Peter Tugwell | 129 | 948 | 125480 |
Gonneke Willemsen | 129 | 575 | 76976 |
Chris J.L.M. Meijer | 128 | 733 | 78705 |