A review of protein adsorption on bioceramics
TLDR
This review will recapitulate the recent studies on the bioceramic–protein interactions and suggest that the adsorption of proteins is critical within the sequence of biological activities.Abstract:
Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic–protein interactions.read more
Citations
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Biocompatible aspects of poly ( 2 - methoxyethylacrylate) (PMEA), relationship between protein adsorption and platelet adhesion on PMEA Surface
TL;DR: Low platelet adhesion and spreading are closely related to the low degree of the denaturation of the protein adsorbed onto PMEA, which could be developed as a promising material to produce a useful blood-contacting surface for medical devices.
Mediation of biomaterial-cell interactions by adsorbed proteins: A review
TL;DR: In this article, a review illustrates the mediation of cell responses to biomaterials by adsorbed proteins, in the context of osteoblasts and selected materials used in orthopedic implants and bone tissue engineering.
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Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona
Manuel Tonigold,Manuel Tonigold,Johanna Simon,Johanna Simon,Diego Estupiñán,Maria Kokkinopoulou,Jonas Reinholz,Jonas Reinholz,Ulrike Kintzel,Ulrike Kintzel,Anke Kaltbeitzel,Patricia Renz,Matthias P. Domogalla,Kerstin Steinbrink,Ingo Lieberwirth,Daniel Crespy,Katharina Landfester,Volker Mailänder,Volker Mailänder +18 more
TL;DR: It is shown that a pre-adsorption process can be used to attach targeting antibodies to the surface of the nanocarrier, potentially a versatile, efficient and rapid method of attaching targeting moieties to thesurface of nanoccarriers.
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Ceramics and Ceramic Coatings in Orthopaedics
TL;DR: Advanced bioceramics and coatings are expected to have increasing use in orthopaedics because of their unique combination and range of properties including strength and toughness, hardness and wear resistance, biocompatibility, bacteriostasis, and osseointegration.
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Structural determinants for protein adsorption/non-adsorption to silica surface.
Christelle Mathé,Christelle Mathé,Stéphanie Devineau,Jean-Christophe Aude,Gilles Lagniel,Stéphane Chédin,Véronique Legros,Marie-Hélène Mathon,Jean Philippe Renault,Serge Pin,Yves Boulard,Yves Boulard,Jean Labarre +12 more
TL;DR: Structural analyses and molecular dynamics simulations of proteins from the two groups indicate that non-adsorbed proteins have twice as many π-π interactions and higher structural rigidity, consistent with the notion that adsorption is correlated with the flexibility of the protein and with its ability to spread on the surface.
References
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.