Journal ArticleDOI
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.
Olof Johnell,John A. Kanis +1 more
TLDR
It is concluded that osteoporotic fractures are a significant cause of morbidity and mortality, particularly in the developed countries.Abstract:
Objective The aim of this study was to quantify the global burden of osteoporotic fracture worldwide. Methods The incidence of hip fractures was identified by systematic review and the incidence of osteoporotic fractures was imputed from the incidence of hip fractures in different regions of the world. Excess mortality and disability weights used age- and sex-specific data from Sweden to calculate the Disability Adjusted Life Years (DALYs) lost due to osteoporotic fracture. Results In the year 2000 there were an estimated 9.0 million osteoporotic fractures of which 1.6 million were at the hip, 1.7 million at the forearm and 1.4 million were clinical vertebral fractures. The greatest number of osteoporotic fractures occurred in Europe (34.8%). The total DALYs lost was 5.8 million of which 51% were accounted for by fractures that occurred in Europe and the Americas. World-wide, osteoporotic fractures accounted for 0.83% of the global burden of non-communicable disease and was 1.75% of the global burden in Europe. In Europe, osteoporotic fractures accounted for more DALYs lost than common cancers with the exception of lung cancer. For chronic musculo-skeletal disorders the DALYs lost in Europe due to osteoporosis (2.0 million) were less than for osteoarthrosis (3.1 million) but greater than for rheumatoid arthritis (1.0 million). Conclusion We conclude that osteoporotic fractures are a significant cause of morbidity and mortality, particularly in the developed countries.read more
Citations
More filters
Journal ArticleDOI
Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis
Steven R. Cummings,Javier San Martin,Michael R. McClung,Ethel S. Siris,Richard Eastell,Ian R. Reid,Pierre D. Delmas,Holly B. Zoog,M. Austin,Andrea Wang,Stepan Kutilek,Silvano Adami,Jose R. Zanchetta,Cesar Libanati,Suresh Siddhanti,Claus Christiansen +15 more
TL;DR: Denosumab given subcutaneously twice yearly for 36 months was associated with a reduction in the risk of vertebral, nonvertebral, and hip fractures in women with osteoporosis.
Journal ArticleDOI
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
John A. Kanis,Eugene V. McCloskey,Helena Johansson,Cyrus Cooper,René Rizzoli,Jean-Yves Reginster +5 more
TL;DR: In this paper, the European Foundation for Osteoporosis and Bone disease (subsequently the International osteopo- rosis Foundation) published guidelines for the diagnosis and management of osteoporrosis in a European setting.
Journal ArticleDOI
Critical review: vegetables and fruit in the prevention of chronic diseases
Heiner Boeing,Angela Bechthold,Achim Bub,Sabine Ellinger,Dirk Haller,Anja Kroke,Eva Leschik-Bonnet,Manfred J. Müller,H Oberritter,Matthias B. Schulze,Peter Stehle,Bernhard Watzl +11 more
TL;DR: This critical review on the associations between the intake of vegetables and fruit and the risk of several chronic diseases shows that a high daily intake of these foods promotes health.
Journal ArticleDOI
Meta-analysis: Excess Mortality After Hip Fracture Among Older Women and Men
Patrick Haentjens,Jay Magaziner,Cathleen S. Colón-Emeric,Dirk Vanderschueren,Koen Milisen,Brigitte Velkeniers,Steven Boonen +6 more
TL;DR: Older adults have a 5- to 8-fold increased risk for all-cause mortality during the first 3 months after hip fracture, and excess annual mortality after hip fractures is higher in men than in women.
Journal ArticleDOI
A systematic review of hip fracture incidence and probability of fracture worldwide
TL;DR: Worldwide, there are marked variations in hip fracture rates and in the 10-year probability of major osteoporotic fractures that cannot be explained by the often multiple sources of error in the ascertainment of cases or the catchment population.
References
More filters
Book
The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Journal ArticleDOI
Epidemiology and outcomes of osteoporotic fractures.
TL;DR: In this paper, epidemiological research was done and used to identify individuals at high risk of disabling fractures, thereby allowing careful allocation of expensive treatments to individuals most in need, which could potentially be as expensive as medical treatment of fractures.
Journal ArticleDOI
Hip fractures in the elderly: A world-wide projection
TL;DR: In this article, the authors applied available incidence rates for hip fracture from various parts of the world to projected populations in 1990, 2025 and 2050 in order to estimate the numbers of hip fractures which might occur in each of the major continental regions.
Hip fractures in the elderly: a worldwide projection
C Cooper,G. Campion,L. J. Melton +2 more
TL;DR: The results suggest that osteoporosis will truly become a global problem over the next half century, and that preventive strategies will be required in parts of the world where they are not currently felt to be necessary.
Journal ArticleDOI
World-wide Projections for Hip Fracture
TL;DR: It is concluded that the socioeconomic impact of hip fractures will increase markedly throughout the world, particularly in Asia, and that there is an urgent need to develop preventive strategies,particularly in the developing countries.