Anatomo-Physiologic Basis for Auricular Stimulation.
TLDR
Accumulating evidence suggests that VNS and TNS share multiple levels and mechanisms of action in the central nervous system, however, the sites and neurobiologic mechanisms by which they produce their therapeutic effects are not clear yet.Abstract:
Introduction: Stimulation of cranial nerves modulates central nervous system (CNS) activity via the extensive connections of their brainstem nuclei to higher-order structures. Clinical exp...read more
Citations
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Journal ArticleDOI
Current directions in the auricular vagus nerve stimulation I - A physiological perspective
Eugenijus Kaniusas,Stefan Kampusch,Marc Tittgemeyer,Marc Tittgemeyer,Fivos Panetsos,Raquel Fernandez Gines,Michele Papa,Attila Kiss,Bruno K. Podesser,Antonino M. Cassarà,Emmeric Tanghe,Amine M. Samoudi,Thomas Tarnaud,Wout Joseph,Vaidotas Marozas,Arunas Lukosevicius,Niko Istuk,Antonio Sarolic,Sarah Lechner,Wlodzimierz Klonowski,Giedrius Varoneckas,Giedrius Varoneckas,Jozsef Constantin Szeles +22 more
TL;DR: Two reviews build a reasonable bridge from the rationale of aVNS as a therapeutic tool to current research lines, all of them being highly relevant for the promising aV NS technology to reach the patient.
Journal ArticleDOI
Current Directions in the Auricular Vagus Nerve Stimulation II - An Engineering Perspective.
Eugenijus Kaniusas,Stefan Kampusch,Marc Tittgemeyer,Fivos Panetsos,Raquel Fernandez Gines,Michele Papa,Attila Kiss,Bruno K. Podesser,Antonino M. Cassarà,Emmeric Tanghe,Amine M. Samoudi,Thomas Tarnaud,Wout Joseph,Vaidotas Marozas,Arunas Lukosevicius,Niko Istuk,Sarah Lechner,Wlodzimierz Klonowski,Giedrius Varoneckas,Giedrius Varoneckas,Jozsef Constantin Szeles,Antonio Sarolic +21 more
TL;DR: Two reviews build a reasonable bridge from the rationale of aVNS as a therapeutic tool to current research lines, all of them being highly relevant for the promising aV NS technology to reach the patient.
Journal ArticleDOI
Auricular Neuromodulation: The Emerging Concept beyond the Stimulation of Vagus and Trigeminal Nerves.
TL;DR: This review of different neurostimulation techniques will focus on sites and mechanisms of both transcutaneous vagus and trigeminal nerve stimulation, which are scientifically validated non-invasive bottom-up brain modulation techniques, easily implemented from the outer ear.
Journal ArticleDOI
Does auriculotherapy have therapeutic effectiveness? An overview of systematic reviews.
TL;DR: Auriculotherapy has shown to have positive effects while associated to conventional treatments of insomnia, chronic and acute pain, and further well designed studies are required to evaluate the effectiveness of this technique in the treatment of other health conditions.
Journal ArticleDOI
Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome
Eugenijus Kaniusas,Jozsef Constantin Szeles,Stefan Kampusch,Nuria Alfageme-Lopez,Daniela Yucuma-Conde,Xie Li,Julio Mayol,Christoph Neumayer,Michele Papa,Fivos Panetsos +9 more
TL;DR: Auricular vagus nerve stimulation is a safe clinical procedure and it could be either an effective treatment for ARDS originated by Covid-19 and similar viruses or a supplementary treatment to actual ARDS therapeutic approaches.
References
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Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Journal ArticleDOI
A technical guide to tDCS, and related non-invasive brain stimulation tools
Adam J. Woods,Andrea Antal,Marom Bikson,Paulo S. Boggio,Andre R. Brunoni,Pablo Celnik,Leonardo G. Cohen,Felipe Fregni,Christoph Herrmann,Emily S. Kappenman,Helena Knotkova,David Liebetanz,Carlo Miniussi,Pedro C. Miranda,Walter Paulus,Davide Reato,Charlotte J. Stagg,Nicole Wenderoth,Michael A. Nitsche,Michael A. Nitsche +19 more
TL;DR: This review covers technical aspects of tES, as well as applications like exploration of brain physiology, modelling approaches, tES in cognitive neurosciences, and interventional approaches to help the reader to appropriately design and conduct studies involving these brain stimulation techniques.
Journal ArticleDOI
Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat
TL;DR: Daly & Evans (1953) studied the effects of electrical stimulation of the caudal cut end of the cervical vagus nerve in the cat after chronic division at various levels and demonstrated further that the vagus nerves as they enter are afferent in function.
Journal ArticleDOI
Reversing pathological neural activity using targeted plasticity
Jonathan Riley,Jonathan D. Seale,William A. Vrana,Jai Shetake,Sindhu P. Sudanagunta,Michael S. Borland,Michael P. Kilgard +6 more
TL;DR: Evidence is reported that reversing the brain changes responsible can eliminate the perceptual impairment in an animal model of noise-induced tinnitus and this method for restoring neural activity to normal may be applicable to a variety of neurological disorders.
Journal ArticleDOI
Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial.
A. John Rush,Lauren B. Marangell,Harold A. Sackeim,Mark S. George,Mark S. George,Stephen K. Brannan,Sonia M. Davis,Robert H Howland,Mitchel A. Kling,Barry R. Rittberg,William J. Burke,Mark Hyman Rapaport,John Zajecka,Andrew A. Nierenberg,Mustafa M. Husain,David Ginsberg,Robert G. Cooke +16 more
TL;DR: This study did not yield definitive evidence of short-term efficacy for adjunctive VNS in treatment-resistant depression.