Journal ArticleDOI
Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation.
TLDR
A resveratrol‐based skin care formulation, with 17 times greater antioxidant activity than idebenone, is reported, which is reviewed and compared with other antioxidants used in skin care products.Abstract:
Resveratrol, an antioxidant polyphenol from red wine, has been the subject of intense interest in recent years due to a range of unique anti-aging properties. These include cardiovascular benefits via increased nitric oxide production, down-regulation of vasoactive peptides, lowered levels of oxidized low-density lipoprotein, and cyclooxygenase inhibition; possible benefits on Alzheimer's disease by breakdown of beta-amyloid and direct effects on neural tissues; phytohormonal actions; anticancer properties via modulation of signal transduction, which translates into anti-initiation, antipromotion, and antiprogression effects; antimicrobial effects; and sirtuin activation, which is believed to be involved in the caloric restriction-longevity effect. Here we report a resveratrol-based skin care formulation, with 17 times greater antioxidant activity than idebenone. The role of resveratrol in prevention of photoaging is reviewed and compared with other antioxidants used in skin care products.read more
Citations
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Journal ArticleDOI
Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis
Xiangli Cui,Yu Jin,Anne B. Hofseth,Edsel A. Peña,Joshua D. Habiger,Alexander A. Chumanevich,Deepak Poudyal,Mitzi Nagarkatti,Prakash S. Nagarkatti,Udai P. Singh,Lorne J. Hofseth +10 more
TL;DR: It is indicated that resveratrol is a useful, nontoxic complementary and alternative strategy to abate colitis and potentially colon cancer associated with colitis.
Journal ArticleDOI
Encapsulation of cosmetic active ingredients for topical application – a review
Francisca Casanova,Lúcia Santos +1 more
TL;DR: Overall discussion on encapsulation of cosmetically active ingredients and encapsulation techniques for cosmetic and personal care products for topical applications and critical aspects and future perspectives are addressed.
Journal ArticleDOI
Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view.
Marcos Roberto de Oliveira,Seyed Fazel Nabavi,Azadeh Manayi,Maria Daglia,Zohreh Hajheydari,Seyed Mohammad Nabavi +5 more
TL;DR: An understanding of the chemistry and source of resveratrol, its bioavailability and the promising effects on mitochondria brings a new hope to therapy of mitochondrial dysfunction-related diseases.
Journal ArticleDOI
Discovering the link between nutrition and skin aging
TL;DR: This review will provide an overview of the current literature “linking” nutrition with skin aging and a variety of plant extracts that have been widely used in the skin care industry either as topically applied agents or oral supplements.
Journal ArticleDOI
Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol.
TL;DR: White wine and its cardioprotective components possess anti-aging properties by feeding rats with resveratrol andhydroxytyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.
References
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Journal ArticleDOI
Oxidants, antioxidants, and the degenerative diseases of aging
TL;DR: It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Journal ArticleDOI
Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine
TL;DR: In in-vitro studies with phenolic substances in red wine and normal human low-density lipoprotein (LDL) the authors found that red wine inhibits the copper-catalysed oxidation of LDL.
Journal ArticleDOI
High absorption but very low bioavailability of oral resveratrol in humans
TL;DR: The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans.