Antiviral Activity of Resveratrol against Human and Animal Viruses
TLDR
This review highlights the antiviral mechanisms of resveratrol in human and animal viral infections and how some of these effects are associated with the antioxidant properties of the compound.Abstract:
Resveratrol is a potent polyphenolic compound that is being extensively studied in the amelioration of viral infections both in vitro and in vivo. Its antioxidant effect is mainly elicited through inhibition of important gene pathways like the NF-κβ pathway, while its antiviral effects are associated with inhibitions of viral replication, protein synthesis, gene expression, and nucleic acid synthesis. Although the beneficial roles of resveratrol in several viral diseases have been well documented, a few adverse effects have been reported as well. This review highlights the antiviral mechanisms of resveratrol in human and animal viral infections and how some of these effects are associated with the antioxidant properties of the compound.read more
Citations
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Evolution patterns of SARS-CoV-2: Snapshot on its genome variants.
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References
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Journal ArticleDOI
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
TL;DR: It is suggested that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases.
Journal ArticleDOI
Bioavailability of resveratrol.
TL;DR: Deconjugation enzymes such as β‐glucuronidase and sulfatase, as well as specific tissue accumulation of resveratrol, may enhance resver atrol efficacy at target sites, and methylated derivatives with improved bioavailability may be important in future research.
Journal ArticleDOI
Antioxidant properties of resveratrol: A structure–activity insight
TL;DR: In this paper, the antioxidant activity of resveratrol was investigated by employing various in vitro assays such as DPPH•, ABTS•, DMPD•+, O2•− and H2O2 scavenging activities, total antioxidant activity, reducing abilities, and Fe2+ chelating activities.
Journal ArticleDOI
Metabolism and bioavailability of trans‐resveratrol
Elisabeth Wenzel,Veronika Somoza +1 more
TL;DR: In order to reveal information on absorption, metabolism, and the consequent bioavailability of resveratrol, different research approaches were performed, including in vitro, ex vivo, and in vivo models, all of which are considered in this review.
Journal ArticleDOI
Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans.
Juan Gambini,Marta Inglés,Gloria Olaso,Raúl López-Grueso,Vicent Bonet-Costa,Lucia Gimeno-Mallench,Cristina Mas-Bargues,Kheira M. Abdelaziz,Mari Carmen Gomez-Cabrera,Jose Viña,Consuelo Borrás +10 more
TL;DR: The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resver atrol.