Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives
TLDR
The functions of bone biomarkers are introduced and then recently developed techniques for bone biomarker measurements have been systematically integrated to discuss the possibility for osteoporosis assessment in the early stage.Abstract:
Bone biomarkers included formation, resorption and regulator are released during the bone remodeling processes. These bone biomarkers have attracted much attention in the clinical assessment of osteoporosis treatment in the past decade. Combination with the measurement of bone mineral density, the clinical applications of bone biomarkers have provided comprehensive information for diagnosis of osteoporosis. However, the analytical approaches of the bone biomarkers are still the challenge for further clinical trials. In this mini-review, we have introduced the functions of bone biomarkers and then recently developed techniques for bone biomarker measurements have been systematically integrated to discuss the possibility for osteoporosis assessment in the early stage.read more
Citations
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Osteoporosis: Current Concepts.
Ibrahim Akkawi,Hassan Zmerly +1 more
TL;DR: Nonpharmacological interventions, which are recommended for all subjects, and pharmacological therapy in all postmenopausal women who have had an osteoporotic fracture or have BMD values consistent with osteopOrosis are recommended.
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Lysyl oxidases: from enzyme activity to extracellular matrix cross-links
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A systematic review and meta-analysis of bone loss in space travelers.
Mariya Stavnichuk,Nicholas Mikolajewicz,Tatsuya Corlett,Tatsuya Corlett,Martin Morris,Svetlana V. Komarova,Svetlana V. Komarova +6 more
TL;DR: A meta-analysis of studies systematically identified from searching Medline, Embase, Web of Science, BIOSIS, NASA Technical reports, and HathiTrust extracted post-flight bone density and biochemical bone marker values for 124 individuals, finding microgravity-induced bone changes depend on the skeletal-site position relative to the gravitational vector.
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Ovariectomized rat model of osteoporosis: a practical guide.
TL;DR: A 4-step guideline for inducing a rat model of osteoporosis by ovariectomy (OVX) is provided, showing that the responses of trabecular bones of proximal tibia, lumbar vertebrae and femur to OVX are similar to those in humans; however, for short-term studies, proximalTibia is recommended.
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Osteoporosis and the Potential of Cell-Based Therapeutic Strategies
TL;DR: The role that MSCs play in the etiopathology of osteoporosis and their potential use for the treatment of this disease are discussed.
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