Journal ArticleDOI
Brain development during childhood and adolescence: a longitudinal MRI study.
Jay N. Giedd,Jonathan D. Blumenthal,Neal Jeffries,F X Castellanos,Hong Liu,Alex P. Zijdenbos,Tomáš Paus,Alan C. Evans,Judith L. Rapoport +8 more
TLDR
This large-scale longitudinal pediatric neuroimaging study confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease.Abstract:
Pediatric neuroimaging studies1,2,3,4,5, up to now exclusively cross sectional, identify linear decreases in cortical gray matter and increases in white matter across ages 4 to 20. In this large-scale longitudinal pediatric neuroimaging study, we confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease. These changes in cortical gray matter were regionally specific, with developmental curves for the frontal and parietal lobe peaking at about age 12 and for the temporal lobe at about age 16, whereas cortical gray matter continued to increase in the occipital lobe through age 20.read more
Citations
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Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI
Dynamic mapping of human cortical development during childhood through early adulthood
Nitin Gogtay,Jay N. Giedd,Leslie Lusk,Kiralee M. Hayashi,Deanna Greenstein,A. Catherine Vaituzis,Tom F. Nugent,David H. Herman,Liv S. Clasen,Arthur W. Toga,Judith L. Rapoport,Paul M. Thompson +11 more
TL;DR: The dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences reveals that higher-order association cortices mature only after lower-order somatosensory and visual cortices are developed.
Book ChapterDOI
Obesity and Overweight
TL;DR: Overweight or obesity in adolescents has reache epidemic proportions in the USA and other industr alized countries and these conditions, although lumped together in research and in commentarie reflect adolescents’ being toward the heavier point a continuum that would range from underweight morbidly obese.
Journal ArticleDOI
The Adolescent Brain
TL;DR: Evidence is provided that there is a heightened responsiveness to incentives and socioemotional contexts during this time, when impulse control is still relatively immature, which suggests differential development of bottom‐up limbic systems to top‐down control systems during adolescence as compared to childhood and adulthood.
Journal ArticleDOI
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Naftali Raz,Ulman Lindenberger,Karen M. Rodrigue,Kristen M. Kennedy,Denise Head,Adrienne Williamson,Cheryl L. Dahle,Denis Gerstorf,James D. Acker +8 more
TL;DR: In this paper, the authors present longitudinal measures of five-year change in the regional brain volumes in healthy adults and assess the average and individual differences in volume changes and the effects of age, sex and hypertension with latent difference score modeling.
References
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Journal ArticleDOI
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Pasko Rakic,Jean-Pierre Bourgeois,Maryellen F. Eckenhoff,Nada Zecevic,Patricia S. Goldman-Rakic +4 more
TL;DR: This isochronic course of synaptogenesis in anatomically and functionally diverse regions indicates that the entire cerebral cortex develops as a whole and that the establishment of cell-to-cell communication in this structure may be orchestrated by a single genetic or humoral signal.
Journal ArticleDOI
Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18
Jay N. Giedd,John Snell,Nicholas Lange,Jagath C. Rajapakse,B. J. Casey,Patricia Kozuch,A. Catherine Vaituzis,Yolanda C. Vauss,Susan D. Hamburger,Debra Kaysen,Judith L. Rapoport +10 more
TL;DR: Findings highlight gender-specific maturational changes of the developing brain and the need for large gender-matched samples in pediatric neuropsychiatric studies.