Journal ArticleDOI
British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008
Brian Gazzard,Jane Anderson,Abdel Babiker,Marta Boffito,Gary Brook,Gary Brough,Duncan Churchill,Ben Cromarty,Satyajit Das,Martin Fisher,Andrew L. Freedman,Anna Maria Geretti,Margaret A. Johnson,Saye Khoo,Clifford Leen,Devaki Nair,Barry Peters,Andrew N. Phillips,Deenan Pillay,Anton Pozniak,John P. Walsh,Ed Wilkins,Ian S. Williams,Matthew Williams,M Youle +24 more
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TLDR
The 2008 BHIVA Guidelines have been updated to incorporate all the new relevant information since the last iteration and all the peer-reviewed publications and important, potentially treatment-changing abstracts from the last 2 years have been reviewed.Abstract:
The 2008 BHIVA Guidelines have been updated to incorporate all the new relevant information (including presentations at the 15th Conference on Retroviruses and Opportunistic Infections 2008) since the last iteration. The guidelines follow the methodology outlined below and all the peer-reviewed publications and important, potentially treatment-changing abstracts from the last 2 years have been reviewed.
The translation of data into clinical practice is often difficult even with the best possible evidence (i.e. two randomized controlled trials) because of trial design, inclusion criteria and precise surrogate marker endpoints (see Appendix). The recommendations based upon expert opinion have the least good evidence but perhaps provide an important reason for writing the guidelines to produce a consensual opinion about current practice. It must, however, be appreciated that such opinion is often wrong and should not stifle research to challenge it.
Similarly, although the Writing Group seeks to provide guidelines to optimize treatment, such care needs to be individualized and we have not constructed a document that we would wish to see used as a ‘standard’ for litigation.read more
Citations
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Journal ArticleDOI
Decline in the AIDS and death rates in the EuroSIDA study: an observational study
Amanda Mocroft,Bruno Ledergerber,Christine Katlama,Ole Kirk,Peter Reiss,A d'Arminio Monforte,Brygida Knysz,M. Dietrich,Andrew N. Phillips,Jens D Lundgren +9 more
TL;DR: The initial drop in mortality and morbidity after the introduction of HAART has been sustained and potential long-term adverse effects associated with HAART have not altered its effectiveness in treating AIDS.
Journal ArticleDOI
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial.
Adriano Lazzarin,Thomas B. Campbell,Bonaventura Clotet,Margaret Johnson,Christine Katlama,Arend Moll,William J. Towner,Benoit Trottier,Monika Peeters,Johan Vingerhoets,Goedele De Smedt,Benny Baeten,Greet Beets,Rekha Sinha,Brian Woodfall +14 more
TL;DR: In treatment-experienced patients with NNRTI resistance, treatment with TMC 125 achieved better virological suppression at week 24 than did placebo, and the safety and tolerability profile of TMC125 was generally comparable with placebo.
Journal ArticleDOI
Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy
Margaret T May,Mark Gompels,Valerie Delpech,Kholoud Porter,Chloe Orkin,Stephen Kegg,Phillip Hay,Margaret Johnson,Adrian Palfreeman,Richard Gilson,David R. Chadwick,Fabiola Martin,Teresa Hill,John Walsh,Frank A. Post,Martin Fisher,Jonathan Ainsworth,Sophie Jose,Clifford Leen,Mark Nelson,Jane Anderson,Caroline A. Sabin +21 more
TL;DR: Patients who started ART with a low CD4+ cell count significantly improve their life expectancy if they have a good CD4- cell count response and undetectable viral load.
Journal ArticleDOI
Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study
Jean-Michel Molina,Jaime Andrade-Villanueva,Juan Echevarria,Ploenchan Chetchotisakd,Jorge Corral,Neal David,Graeme Moyle,Marco Mancini,Lisa Percival,Rong Yang,Alexandra Thiry,Donnie McGrath +11 more
TL;DR: In treatment-naive patients, atazanavir/ritonavir once-daily demonstrated similar antiviral efficacy to lopinavIR/rit onavir twice-daily, with less gastrointestinal toxicity but with a higher rate of hyperbilirubinaemia.
Journal ArticleDOI
Changes in the risk of death after HIV seroconversion compared with mortality in the general population.
Krishnan Bhaskaran,Osamah Hamouda,Mette Sannes,Faroudy Boufassa,Anne M Johnson,Paul C. Lambert,Kholoud Porter +6 more
TL;DR: In industrialized countries, persons infected sexually with HIV now appear to experience mortality rates similar to those of the general population in the first 5 years following infection, though a mortality excess remains as duration of HIV infection lengthens.
References
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Journal ArticleDOI
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
Frank J. Palella,Kathleen M. Delaney,Anne C. Moorman,Mark O. Loveless,Jack Fuhrer,Glen A. Satten,Diane J. Aschman,Scott D. Holmberg +7 more
TL;DR: The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies.
Journal ArticleDOI
HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
TL;DR: A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease, providing not only a kinetic picture ofAIDS pathogenesis, but also theoretical principles to guide the development of treatment strategies.
Journal ArticleDOI
Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.
David L. Paterson,Susan Swindells,J. Mohr,Michelle Brester,Emanuel N. Vergis,Cheryl Squier,Marilyn M. Wagener,Nina Singh +7 more
TL;DR: Given the critical importance of adherence to therapy to patient outcome, secondary prevention of HIV infection, and willingness of providers to prescribe therapy, this prospectively investigated the association between protease inhibitor adherence and patient outcome and factors related to adherence.
Journal Article
Revised Recommendations for HIV Testing of Adults, Adolescents, and Pregnant Women in Health-Care Settings
Bernard M. Branson,H. Hunter Handsfield,Margaret A. Lampe,Robert S. Janssen,Allan W. Taylor,Sheryl B. Lyss,Jill Clark +6 more
TL;DR: The objectives of these recommendations are to increase HIV screening of patients, including pregnant women, in health-care settings; foster earlier detection of HIV infection; identify and counsel persons with unrecognized HIV infection and link them to clinical and prevention services; and further reduce perinatal transmission of HIV in the United States.
A longitudinal study
TL;DR: A longitudinal study of service delivery within MRI services at Auckland University for patients, researchers and referring practitioners has been carried out since 2006 as mentioned in this paper, with a focus on the effects of service provision on patient satisfaction.
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