Cesarean versus Vaginal Delivery: Long term infant outcomes and the Hygiene Hypothesis
Josef Neu,Jona Rushing +1 more
TLDR
The authors provided background about the human microbiota and its relationship to the developing immune system as well as the relationship of mode of delivery on the colonization of the infant intestine, development of the immune system, and subsequent childhood allergies, asthma, and autoimmune diseases.About:
This article is published in Clinics in Perinatology.The article was published on 2011-06-01 and is currently open access. It has received 435 citations till now. The article focuses on the topics: Hygiene hypothesis.read more
Citations
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How colonization by microbiota in early life shapes the immune system
TL;DR: The role of early-life education of the immune system during this “window of opportunity,” when disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets is discussed.
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The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota
Christian Milani,Sabrina Duranti,Francesca Bottacini,Eoghan Casey,Francesca Turroni,Jennifer Mahony,Clara Belzer,Susana Delgado Palacio,Silvia Arboleya Montes,Leonardo Mancabelli,Gabriele Andrea Lugli,Juan M. Rodríguez,Lars Bode,Willem M. de Vos,Willem M. de Vos,Miguel Gueimonde,Abelardo Margolles,Douwe van Sinderen,Marco Ventura +18 more
TL;DR: The infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions are described and the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease are discussed.
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Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months
Meghan B. Azad,Theodore Konya,Heather Maughan,David S. Guttman,Catherine J. Field,Radha Chari,Malcolm R. Sears,Allan B. Becker,James A. Scott,Anita L. Kozyrskyj +9 more
TL;DR: The gut microbiota of healthy Canadian infants is characterized and the effects of delivery mode and infant diet as determinants of this essential microbial community in early life are described and advance the understanding of the gut microbiota in healthy infants.
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Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis.
TL;DR: It is suggested that gut‐microbial products can affect chromatin plasticity within their host's brain that in turn leads to changes in neuronal transcription and eventually alters host behaviour, and that the microbiota itself may be viewed as an epigenetic entity.
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The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review
TL;DR: The diversity and colonization pattern of the gut microbiota were significantly associated to the mode of delivery during the first three months of life, however the observed significant differences disappears after 6 months of infants life.
References
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A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
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Epidemiology and causes of preterm birth
TL;DR: A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth.
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Hay fever, hygiene, and household size.
TL;DR: A possible explanation forHay fever trends over time is suggested, as well as a recent increase in the prevalence of asthma2 and childhood eczema.
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Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
Maria Gloria Dominguez-Bello,Elizabeth K. Costello,Elizabeth K. Costello,Monica Contreras,Magda Magris,Glida Hidalgo,Noah Fierer,Rob Knight +7 more
TL;DR: It is found that in direct contrast to the highly differentiated communities of their mothers, neonates harbored bacterial communities that were undifferentiated across multiple body habitats, regardless of delivery mode.
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Gut flora in health and disease
TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.