Journal ArticleDOI
Circular RNA: A new star of noncoding RNAs
Shibin Qu,Xisheng Yang,Xiaolei Li,Jianlin Wang,Yuan Gao,Runze Shang,Wei Sun,Kefeng Dou,Haimin Li +8 more
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TLDR
Similar to miRNAs and long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the field of RNA and could be widely involved in the processes of life.About:
This article is published in Cancer Letters.The article was published on 2015-09-01. It has received 1317 citations till now. The article focuses on the topics: Circular RNA & microRNA.read more
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ceRNA in cancer: possible functions and clinical implications
TL;DR: The mechanisms and molecular bases of ceRNA networks are introduced, their roles in the pathogenesis of cancer as well as methods of predicting and validating ceRNA interplay are discussed and the possibilities of ceRNAs as diagnostic biomarkers or therapeutic targets are envisioned.
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Circular RNAs are miRNA sponges and can be used as a new class of biomarker.
TL;DR: The biogenesis, properties and function of endogenous circRNA sponges, with a special focus on those related to human cancer, are reviewed and the possibility of using circRNAs as molecular markers for the diagnosis of diseases is discussed.
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Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations
Jlenia Guarnerio,Marco Bezzi,Jong Cheol Jeong,Stella V. Paffenholz,Kelsey Berry,Matteo M. Naldini,Francesco Lo-Coco,Yvonne Tay,Andrew H. Beck,Pier Paolo Pandolfi +9 more
TL;DR: It is shown that well-established cancer-associated chromosomal translocations give rise to fusion circRNAs (f-circRNA) that are produced from transcribed exons of distinct genes affected by the translocations.
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Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway
Xing Zhang,Sen Wang,Haixiao Wang,Jiacheng Cao,Xiaoxu Huang,Zheng Chen,Penghui Xu,Guangli Sun,Jianghao Xu,Jialun Lv,Zekuan Xu +10 more
TL;DR: It is proved that circNRIP1 sponges miR-149-5p to affect the expression level of AKT1 and eventually acts as a tumour promotor in GC and demonstrated that quaking can promote circ NRIP1 transcription.
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CircRNA: a novel type of biomarker for cancer
TL;DR: Based on the function ofcircRNAs in cancer, it is believed that circRNAs may serve as diagnostic or tumor promising biomarkers and provide a new therapeutic target for the treatment of cancer.
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Journal Article
Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
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Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
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Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.
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Circular RNAs are abundant, conserved, and associated with ALU repeats
William R. Jeck,Jessica A. Sorrentino,Kai Wang,Michael K. Slevin,Christin E. Burd,Jinze Liu,William F. Marzluff,Norman E. Sharpless +7 more
TL;DR: High-throughput sequencing of libraries prepared from ribosome-depleted RNA with or without digestion with the RNA exonuclease showed that ecircRNAs are abundant, stable, conserved and nonrandom products of RNA splicing that could be involved in control of gene expression.