Current Thoughts in Fungal Keratitis: Diagnosis and Treatment
TLDR
This review will discuss current diagnostic modalities of fungal keratitis and will particularly focus on treatment regimens, and explore future therapeutic models and critique the potential benefit of each.Abstract:
Fungal keratitis remains a challenging and often elusive diagnosis in geographic regions where it is endemic. Marred by delays in diagnosis, the sequelae of corneal fungal infections, though preventable, can be irreversible. Recent studies and advances in the arena have broadened the approach and treatment to mycotic keratitis. This review will discuss current diagnostic modalities of fungal keratitis and will particularly focus on treatment regimens. It will also explore future therapeutic models and critique the potential benefit of each.read more
Citations
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Journal ArticleDOI
Pathogenesis of microbial keratitis
TL;DR: The treatment of microbial keratitis should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue.
Journal ArticleDOI
The global incidence and diagnosis of fungal keratitis.
TL;DR: The fungal keratitis diagnostic literature is discussed, the global burden through a complete systematic literature review is estimated and an inexpensive, simple diagnostic method and affordable treatment are needed in every country.
Journal ArticleDOI
Natamycin solid lipid nanoparticles - sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization.
Ahmed Khames,Ahmed Khames,Mohammad A. Khaleel,Mohamed F. El-Badawy,Mohamed F. El-Badawy,Ahmed O. H. El-Nezhawy +5 more
TL;DR: Natamycin solid lipid nanoparticles (NAT-SLNs) represent a promising ocular delivery system for treatment of deep corneal keratitis and were found to be non-irritating toCorneal tissue.
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Treatment of fungal keratitis by penetrating keratoplasty
TL;DR: KP is an effective treatment for fungal keratitis that does not respond to antifungal medication and early surgical intervention before deterioration is recommended.
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Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
Jesús F. Aparicio,Eva G. Barreales,Tamara D. Payero,Cláudia M. Vicente,Antonio de Pedro,Javier Santos-Aberturas +5 more
TL;DR: The molecular genetics, uses, mode of action, analogue generation, regulation and strategies for increasing pimaricin production yields are described and discussed.
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