Electrochemically deposited metal nanoparticles for enhancing the performance of microfluidic MEMS in biochemical analysis

TLDR: In this paper, the fabrication and evaluation of the analytical performance of integrated microfluidic MEMS modified with electrochemically deposited metal nanoparticles are described. And the nanoparticles-modified micro electrodes were characterised electrochemitatively and using scanning electron microscope (SEM).

Abstract: The fabrication and evaluation of the analytical performance of integrated microfluidic MEMS modified with electrochemically deposited metal nanoparticles are described in this paper. The microfluidic MEMS is a hydride system that comprise two layers, poly-dimethylsiloxane (PDMS) and glass, which in turn enclose a micro channels network and a set of 15 micro electrodes, respectively. The mechanism of electrokinetic phenomenon and electrochemical detection were applied for performing injection and separation, and sensing the components of a biochemical mixture, respectively. The technique of electrochemical deposition was employed for depositing nanoparticles of gold, palladium and platinum on the surface of integrated microelectrodes. The nanoparticles-modified micro electrodes were characterised electrochemically and using scanning electron microscope (SEM). Importantly, the nanoparticles-based decoupler has significantly enhanced the analytical performance of the microfluidic MEMS, where detection limits in the low nanomolar range were recorded for the targeted analytes.