Estimates of the severity of coronavirus disease 2019: a model-based analysis.
Robert Verity,Lucy C Okell,Ilaria Dorigatti,Peter Winskill,Charles Whittaker,Natsuko Imai,Gina Cuomo-Dannenburg,Hayley A Thompson,Patrick G T Walker,Han Fu,Amy Dighe,Jamie T. Griffin,Marc Baguelin,Sangeeta N. Bhatia,A Boonyasiri,Anne Cori,Zulma M. Cucunubá,Richard G. FitzJohn,Katy A. M. Gaythorpe,W Green,Arran Hamlet,Wes Hinsley,Daniel J Laydon,Gemma Nedjati-Gilani,Steven Riley,Sabine L. van Elsland,Erik M. Volz,Haowei Wang,Y Wang,Xiaoyue Xi,Christl A. Donnelly,Christl A. Donnelly,Azra C. Ghani,Neil M. Ferguson +33 more
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TLDR
These early estimates give an indication of the fatality ratio across the spectrum of COVID-19 disease and show a strong age gradient in risk of death.Citations
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Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.
Gill Livingston,Gill Livingston,Jonathan Huntley,Andrew Sommerlad,Andrew Sommerlad,David Ames,Clive Ballard,Sube Banerjee,Carol Brayne,Alistair Burns,Jiska Cohen-Mansfield,Claudia Cooper,Sergi G. Costafreda,Amit Dias,Nick C. Fox,Laura N. Gitlin,Robert Howard,Helen C. Kales,Mika Kivimäki,Eric B. Larson,Adesola Ogunniyi,Vasiliki Orgeta,Karen Ritchie,Kenneth Rockwood,Elizabeth L Sampson,Quincy M. Samus,Lon S. Schneider,Geir Selbæk,Linda Teri,Naaheed Mukadam +29 more
TL;DR: Author(s): Livingston, Gill; Huntley, Jonathan; Sommerlad, Andrew ; Sommer Glad, Andrew; Ames, David; Ballard, Clive; Banerjee, Sube; Brayne, Carol; Burns, Alistair; Cohen-Mansfield, Jiska; Cooper, Claudia; Costafreda, Sergi G; Dias, Amit; Fox, Nick; Gitlin, Laura N; Howard, Robert; Kales, Helen C;
Journal ArticleDOI
Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe.
Seth Flaxman,Swapnil Mishra,Axel Gandy,H. Juliette T. Unwin,Thomas A. Mellan,Helen Coupland,Charles Whittaker,Harrison Zhu,Tresnia Berah,Jeffrey W. Eaton,Melodie Monod,Azra C. Ghani,Christl A. Donnelly,Christl A. Donnelly,Steven Riley,Michaela A. C. Vollmer,Neil M. Ferguson,Lucy C Okell,Samir Bhatt +18 more
TL;DR: The results show that major non-pharmaceutical interventions and lockdown in particular have had a large effect on reducing transmission and continued intervention should be considered to keep transmission of SARS-CoV-2 under control.
Journal ArticleDOI
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
Annemarie B Docherty,Ewen M Harrison,Christopher A Green,Hayley E Hardwick,Riinu Pius,Lisa Norman,Karl A Holden,Jonathan M. Read,Frank Dondelinger,Gail Carson,Laura Merson,James A. Lee,Daniel Plotkin,Louise Sigfrid,Sophie Halpin,Clare Jackson,Carrol Gamble,Peter Horby,Jonathan S. Nguyen-Van-Tam,Antonia Ho,Clark D Russell,Jake Dunning,Jake Dunning,Peter J. M. Openshaw,J Kenneth Baillie,Malcolm G Semple +25 more
TL;DR: In study participants, mortality was high, independent risk factors were increasing age, male sex, and chronic comorbidity, including obesity, and the importance of pandemic preparedness and the need to maintain readiness to launch research studies in response to outbreaks is shown.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Clinical Characteristics of Coronavirus Disease 2019 in China.
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