Journal ArticleDOI
Extracorporeal circulation in neonatal respiratory failure: A prospective randomized study
TLDR
A prospective controlled randomized study of the use of extracorporeal membrane oxygenation to treat newborns with respiratory failure using the "randomized play-the-winner" statistical method, which allows lung rest and improves survival compared to conventional ventilator therapy in newborn infants with severe respiratory failure.About:
This article is published in Journal of Critical Care.The article was published on 1987-03-01. It has received 549 citations till now. The article focuses on the topics: Extracorporeal circulation.read more
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Journal ArticleDOI
Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial.
Giles J. Peek,Miranda Mugford,Ravindranath Tiruvoipati,Andrew Wilson,Elizabeth Allen,Mariamma M. Thalanany,Clare Hibbert,Ann Truesdale,Felicity Clemens,Nicola J. Cooper,Richard K. Firmin,Diana Elbourne +11 more
TL;DR: Transfer of adult patients with severe but potentially reversible respiratory failure, whose Murray score exceeds 3.0 or who have a pH of less than 7.20 on optimum conventional management, to a centre with an ECMO-based management protocol is recommended to significantly improve survival without severe disability.
Journal ArticleDOI
Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas
Robert G. Maki,J. Kyle Wathen,Shreyaskumar Patel,Dennis A. Priebat,Scott H. Okuno,Brian L. Samuels,Michael P. Fanucchi,David C. Harmon,Scott M. Schuetze,Denise Reinke,Peter F. Thall,Robert S. Benjamin,Laurence H. Baker,Martee L. Hensley +13 more
TL;DR: Gem citabine as a single agent and the combination of gemcitabine and docetaxel have activity in patients with metastatic soft tissue sarcoma are found to have activity.
Journal ArticleDOI
Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study.
P. Pearl O'Rourke,Robert K. Crone,Joseph P. Vacanti,James H. Ware,Craig W. Lillehei,Richard B. Parad,Michael F. Epstein +6 more
TL;DR: Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which extracorporeal membrane oxygenation (ECMO) therapy was compared with conventional medical therapy (CMT).
Journal ArticleDOI
Extracorporeal Life Support for Severe Acute Respiratory Distress Syndrome in Adults
Mark R. Hemmila,Stephen A. Rowe,Tamer N. Boules,Judiann Miskulin,J W McGillicuddy,Douglas J. E. Schuerer,Jonathan W. Haft,Fresca Swaniker,Saman Arbabi,Ronald B. Hirschl,Robert H. Bartlett +10 more
TL;DR: Extracorporeal life support for severe ARDS in adults is a successful therapeutic option in those patients who do not respond to conventional mechanical ventilator strategies.
Journal ArticleDOI
Extracorporeal Life Support: The University of Michigan Experience
TL;DR: The University of Michigan experience with extracorporeal life support (ECLS) in 1000 consecutive patients between 1980 and 1998 is the largest series at one institution in the world and has shown that ECLS saves lives of patients with acute cardiac or pulmonary failure in a variety of clinical settings.