Journal ArticleDOI
Extracorporeal circulation in neonatal respiratory failure: A prospective randomized study
TLDR
A prospective controlled randomized study of the use of extracorporeal membrane oxygenation to treat newborns with respiratory failure using the "randomized play-the-winner" statistical method, which allows lung rest and improves survival compared to conventional ventilator therapy in newborn infants with severe respiratory failure.About:
This article is published in Journal of Critical Care.The article was published on 1987-03-01. It has received 549 citations till now. The article focuses on the topics: Extracorporeal circulation.read more
Citations
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Journal ArticleDOI
Selective heparinization of the extracorporeal membrane oxygenation circuit using continuous infusions of protamine and heparin in a short-term pig model.
TL;DR: 'selective' heparinization of the ECMO circuit is possible using continuous infusions of protamine and heparine in a short-term piglet model using a continuous infusion near the venous catheter as blood enters the circuit.
Dissertation
Outcome-dependent randomisation schemes for clinical trials with fluctuations in patient characteristics
TL;DR: In this article, the authors investigate the efficiency of estimation and the effect of instability in the response variable for allocation schemes which are aimed at reducing the number of patients who receive the inferior treatment.
Journal ArticleDOI
Uses of extracorporeal membrane oxygenation in nonneonatal respiratory patients. An update.
TL;DR: A broad diagnostic group of nonneonatal patients has now been supported by several different modes of ECMO with encouraging results, and selection criteria for nonne onatal patients that differ from those used for neonatal patients are emerging.
Journal ArticleDOI
Managing our first breaths: a reflection on the past several decades of neonatal pulmonary therapy.
TL;DR: Advances in mechanical ventilation, adjuvant therapies, and respiratory drugs through the past few decades are reviewed and future directions in this field are speculated on.
Journal ArticleDOI
Balancing statistical and ethical considerations in planning clinical trials: recommendations for response-adaptive randomization urn designs
TL;DR: It is concluded that Modified Play-the-Winner tends to be unpredictable and can result in allocation of all of the patients to the better treatment, while Randomized Play- the-Winner and Birth-and-Death Urn with Immigration produce allocations that have comparable powers to equal allocation design.