Journal ArticleDOI
Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model.
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TLDR
CCl4 activates tumor necrosis factor (TNF)alpha, nitric oxide (NO), and transforming growth factors (TGF)-alpha and -beta in the cell, processes that appear to direct the cell primarily toward (self-)destruction or fibrosis.Abstract:
(2003). Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model. Critical Reviews in Toxicology: Vol. 33, No. 2, pp. 105-136.read more
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Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
Willscott E. Naugler,Toshiharu Sakurai,Sunhwa Kim,Shin Maeda,Kyounghyun Kim,Ahmed M. Elsharkawy,Ahmed M. Elsharkawy,Michael Karin +7 more
TL;DR: It is proposed that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males.
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Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors.
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Chlorinated volatile organic compounds (Cl-VOCs) in environment - sources, potential human health impacts, and current remediation technologies.
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Biotransformation of Xenobiotics
TL;DR: The metabolic fate of a xenobiotic can have an important bearing on its toxic potential, the disposition of the compound in the body and the excretion of the compounds.
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c-Jun N-Terminal Kinase Plays a Major Role in Murine Acetaminophen Hepatotoxicity
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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
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Free radical mechanisms in tissue injury
TL;DR: This short review of free radicals discusses certain types of free radical, such as nitroxyl-radicals and free radicals stabilized by steric or derealization features, which are stable enough to be crystallised and stored at temperatures above 0°.
Journal ArticleDOI
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
John J. Lemasters,Anna Liisa Nieminen,Ting Qian,Lawrence C. Trost,Lawrence C. Trost,Steven P. Elmore,Yoshiya Nishimura,Ruth A. Crowe,Wayne E. Cascio,Cynthia A. Bradham,David A. Brenner,Brian Herman +11 more
TL;DR: In vitro findings suggest that the MPT is the pathophysiological mechanism underlying Reye's syndrome in vivo, and a model is proposed in which onset of theMPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death.
Journal ArticleDOI
Mechanisms of carbon tetrachloride toxicity
TL;DR: Le CCl 4 provoque une degenerescence lipidique et une necrose centrolobulaire du foie dans la peroxydation lipidique and les troubles hepatocellulaires de l'homeostase du calcium.
Journal ArticleDOI
Mechanisms of Hepatotoxicity
Hartmut Jaeschke,Gregory J. Gores,Arthur I. Cederbaum,Jack A. Hinson,Dominique Pessayre,John J. Lemasters +5 more
TL;DR: This review addresses recent advances in specific mechanisms of hepatotoxicity, including inducible nitric oxide synthase knockout mice, where nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead.
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