Journal ArticleDOI
Hidden Killers: Human Fungal Infections
Gordon D. Brown,David W. Denning,Neil A. R. Gow,Stuart M. Levitz,Mihai G. Netea,Theodore C. White +5 more
TLDR
The importance of fungi as human pathogens is highlighted and the challenges the authors face in combating the devastating invasive infections caused by these microorganisms are discussed, in particular in immunocompromised individuals.Citations
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Journal ArticleDOI
Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
TL;DR: The accuracy of the estimation of the burden of serious fungal infections country by country for over 5.7 billion people is questioned in the 43 published papers within the LIFE initiative.
Journal ArticleDOI
Worldwide emergence of resistance to antifungal drugs challenges human health and food security
TL;DR: To avoid a global collapse in the ability to control fungal infections and to avoid critical failures in medicine and food security, the authors must improve the stewardship of extant chemicals, promote new antifungal discovery, and leverage emerging technologies for alternative solutions.
Journal ArticleDOI
Bioaerosols in the Earth system: Climate, health, and ecosystem interactions
Janine Fröhlich-Nowoisky,Christopher J. Kampf,Christopher J. Kampf,Bettina Weber,J. Alex Huffman,Christopher Pöhlker,Meinrat O. Andreae,Naama Lang-Yona,Susannah M. Burrows,Sachin S. Gunthe,W. Elbert,Hang Su,Peter Hoor,Eckhard Thines,Thorsten Hoffmann,Viviane R. Després,Ulrich Pöschl +16 more
TL;DR: A review of the state of bioaerosol research, highlights recent advances, and outlines future perspectives in terms of identification, characterization, transport and transformation processes, as well as their interactions with climate, health, and ecosystems, focusing on the role bio-aerosols play in the Earth system.
Journal ArticleDOI
The global problem of antifungal resistance: prevalence, mechanisms, and management
TL;DR: An effective antifungal stewardship programme is essential to control drug resistance, and should incorporate rapid fungal diagnostics, therapeutic drug monitoring, and clinical intervention teams.
Journal ArticleDOI
The gut mycobiome of the Human Microbiome Project healthy cohort
Andrea K. Nash,Thomas A. Auchtung,Matthew C. Wong,Daniel P. Smith,Jonathan R. Gesell,Matthew C. Ross,Christopher J. Stewart,Ginger A. Metcalf,Donna M. Muzny,Richard A. Gibbs,Nadim J. Ajami,Joseph F. Petrosino +11 more
TL;DR: The gut mycobiome of the Human Microbiome Project (HMP) cohort was investigated by sequencing the Internal Transcribed Spacer 2 (ITS2) region as well as the 18S rRNA gene, suggesting that it is a more sensitive method for studying the mycoboome of stool samples.
References
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Journal ArticleDOI
Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study
Hilmar Wisplinghoff,Tammy Bischoff,Sandra M. Tallent,Harald Seifert,Richard P. Wenzel,Michael B. Edmond +5 more
TL;DR: The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
Journal ArticleDOI
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
TL;DR: Improved non-culture-based diagnostics are needed to expand the potential for preemptive (or early directed) therapy and improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC.
Journal ArticleDOI
Emerging fungal threats to animal, plant and ecosystem health.
Matthew C. Fisher,Daniel A. Henk,Cheryl J. Briggs,John S. Brownstein,Lawrence C. Madoff,Sarah L. McCraw,Sarah J. Gurr +6 more
TL;DR: It is argued that nascent fungal infections will cause increasing attrition of biodiversity, with wider implications for human and ecosystem health, unless steps are taken to tighten biosecurity worldwide.
Journal ArticleDOI
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.
Benjamin J. Park,Kathleen Wannemuehler,Barbara J. Marston,Nelesh P. Govender,Peter G. Pappas,Tom Chiller +5 more
TL;DR: The first attempt to estimate the global burden of cryptococcal meningitis finds the number of cases and deaths to be very high, with most occurring in sub-Saharan Africa.
Journal ArticleDOI
Estimation of HIV Incidence in the United States
H. Irene Hall,Ruiguang Song,Philip Rhodes,Joseph Prejean,Qian An,Lisa M. Lee,John M. Karon,Ron Brookmeyer,Edward H. Kaplan,Matthew T. McKenna,Robert S. Janssen +10 more
TL;DR: This study provides the first direct estimates of HIV incidence in the United States using laboratory technologies previously implemented only in clinic-based settings and indicated that HIV incidence increased in the mid-1990s, then slightly declined after 1999 and has been stable thereafter.