Inflammation in wound repair: molecular and cellular mechanisms.
TLDR
Cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair are reviewed and a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response is provided.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2007-03-01 and is currently open access. It has received 1874 citations till now. The article focuses on the topics: Inflammation & Wound healing.read more
Citations
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Journal ArticleDOI
Wound Repair and Regeneration
J.M. Reinke,H. Sorg +1 more
TL;DR: This review focuses on the healing processes of the skin and highlights the classical wound healing phases and the physiological endpoint of mammalian wound repair displays the formation of a scar, which is directly linked to the extent of the inflammatory process throughout wound healing.
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Wound repair and regeneration: Mechanisms, signaling, and translation
TL;DR: In this review, emerging concepts in tissue regeneration and repair are highlighted, and some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies are provided.
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Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches
TL;DR: This review extensively discusses the multifunctional bio-applications of AgNPs; for example, as antibacterial, antifungal, antiviral,Anti-inflammatory, anti-angiogenic, and anti-cancer agents, and the mechanism of the anti- cancer activity of Ag NPs.
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Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation
Stephen J. Jenkins,Dominik Rückerl,Peter C. Cook,Lucy H. Jones,Fred D. Finkelman,Fred D. Finkelman,Nico van Rooijen,Andrew S. MacDonald,Judith E. Allen +8 more
TL;DR: It is revealed that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density, and expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells.
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Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials
TL;DR: A focus of this review is to outline the up-to-date knowledge on immune responses to biomaterials and highlight recent approaches of biommaterials that mimic the physiological extracellular matrix and modify cellular immune responses.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
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Cutaneous wound healing.
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
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Wound Healing--Aiming for Perfect Skin Regeneration
TL;DR: Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.