Journal ArticleDOI
Molecular and functional diversity of vascular endothelial growth factors.
Yasuo Yamazaki,Takashi Morita +1 more
TLDR
The molecular and functional diversity of VEGF family proteins play multiple physiological roles, such as angiogenesis and lymphangiogenesis, while exogenous members (viral and snake venom VEGFs) display activities that are unique in physiology and function.Abstract:
Members of the vascular endothelial growth factor (VEGF) family are crucial regulators of neovascularization and are classified as cystine knot growth factors that specifically bind cellular receptor tyrosine kinases VEGFR-1, VEGFR-2, and VEGFR-3 with high but variable affinity and selectivity. The VEGF family has recently been expanded and currently comprises seven members: VEGF-A, VEGF-B, placenta growth factor (PlGF), VEGF-C, VEGF-D, viral VEGF (also known as VEGF-E), and snake venom VEGF (also known as VEGF-F). Although all members are structurally homologous, there is molecular diversity among the subtypes, and several isoforms, such as VEGF-A, VEGF-B, and PlGF, are generated by alternative exon splicing. These splicing isoforms exhibit differing properties, particularly in binding to co-receptor neuropilins and heparin. VEGF family proteins play multiple physiological roles, such as angiogenesis and lymphangiogenesis, while exogenous members (viral and snake venom VEGFs) display activities that are unique in physiology and function. This review will highlight the molecular and functional diversity of VEGF family proteins.read more
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Journal ArticleDOI
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
TL;DR: Improvements have been made in delineating the VEGFR-2 specific intracellular signalling cascades leading to proliferation, migration, survival and increased permeability, each of which contributes to the angiogenic response.
Journal Article
Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis.
Carmen Stanca Melincovici,Adina Bianca Boşca,Sergiu Susman,Mariana Mărginean,Carina Mihu,Mihnea Istrate,Ioana Maria Moldovan,Alexandra Roman,Carmen Mihaela Mihu +8 more
TL;DR: This article aims to highlight the most recent data referring to the VEGF family and its receptors, as well as its implications in the angiogenesis process.
Journal ArticleDOI
Mesenchymal Stem Cell Migration and Tissue Repair.
TL;DR: The effects of several main regulatory factors on BMSC migration and its underlying mechanism are reviewed; two critical roles of BMSCs—namely, directed differentiation and the paracrine function—in tissue repair are discussed; and insight is provided into the relationship between B MSCs migration and tissue repair.
Journal ArticleDOI
VEGF: an Essential Mediator of Both Angiogenesis and Endochondral Ossification:
J. Dai,A B M Rabie +1 more
TL;DR: Current findings on endochondral ossification are discussed, with emphasis on VEGF-A action in osteoblasts,chondroblasts, and chondroclasts/osteoclasts and regulatory mechanisms involving oxygen tension, and some growth factors and hormones.
Journal ArticleDOI
VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis
Franco Scaldaferri,Stefania Vetrano,Miquel Sans,Vincenzo Arena,Giuseppe Straface,Egidio Stigliano,Alessandro Repici,Andreas Sturm,Alberto Malesci,Julián Panés,Seppo Ylä-Herttuala,Claudio Fiocchi,Silvio Danese +12 more
TL;DR: VEGF-A appears to be a novel mediator of IBD by promoting intestinal angiogenesis and inflammation, and agents that block VEGf-A signaling might reduce intestinal inflammation in patients with IBD.
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