Institution
Meiji Pharmaceutical University
Education•Tokyo, Japan•
About: Meiji Pharmaceutical University is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 1320 authors who have published 2029 publications receiving 47415 citations. The organization is also known as: Meiji Yakka Daigaku.
Topics: Population, Gene, Malassezia, Total synthesis, Fabry disease
Papers published on a yearly basis
Papers
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TL;DR: Its sequence shows that the c-erb-B-2 gene encodes a possible receptor protein and allows an analysis of the similarity of the protein to the EGF receptor and the neu product.
Abstract: A novel v-erb-B-related gene, c-erb-B-2, which has been identified in the human genome, maps to human chromosome 17 at q21 (ref. 40), and seems to encode a polypeptide with a kinase domain that is highly homologous with, but distinct from, that of the epidermal growth factor (EGF) receptor. The c-erb-B-2 gene is conserved in vertebrates and it has been suggested that the neu gene, detected in a series of rat neuro/glioblastomas, is, in fact, the rat c-erb-B-2 gene. Amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process. To determine the nature of the c-erb-B-2 protein, we have now molecularly cloned complementary DNA for c-erb-B-2 messenger RNA prepared from MKN-7 cells. Its sequence shows that the c-erb-B-2 gene encodes a possible receptor protein and allows an analysis of the similarity of the protein to the EGF receptor and the neu product. As a consequence of chromosomal aberration in MKN-7 cells, a 4.6-kilobase (kb) normal transcript and a truncated 2.3-kb transcript of c-erb-B-2 are synthesized at elevated levels. The latter transcript presumably encodes only the extracellular domain of the putative receptor.
1,259 citations
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TL;DR: 3-mercaptopyruvate sulfurtransferase (3MST) in combination with Cysteine aminotransferase (CAT) produces H(2)S from cysteine, and the levels of bound sulfane sulfur are greatly increased in the cells expressing 3MST and CAT but not increased in cells expressing functionally defective mutant enzymes.
Abstract: Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant. Currently, pyridoxal-5'-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain. We recently found that brain homogenates of CBS-knockout mice, even in the absence of PLP, produce H(2)S at levels similar to those of wild-type mice, suggesting the presence of another H(2)S-producing enzyme. Here we show that 3-mercaptopyruvate sulfurtransferase (3MST) in combination with cysteine aminotransferase (CAT) produces H(2)S from cysteine. In addition, 3MST is localized to neurons, and the levels of bound sulfane sulfur, the precursor of H(2)S, are greatly increased in the cells expressing 3MST and CAT but not increased in cells expressing functionally defective mutant enzymes. These data present a new perspective on H(2)S production and storage in the brain.
819 citations
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Imperial College London1, University of Glasgow2, British Heart Foundation3, Meiji Pharmaceutical University4, Crucell5, National Institutes of Health6, Federal University of Rio de Janeiro7, Beth Israel Deaconess Medical Center8, VU University Amsterdam9, Temple University10, University of Naples Federico II11
TL;DR: It is shown that FX binds to the Ad5 hexon, not fiber, via an interaction between the FX Gla domain and hypervariable regions of the hexon surface, which reveals an unanticipated function for hexon in mediating liver gene transfer in vivo.
625 citations
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TL;DR: It is concluded that, although by different mechanisms, both heterozygous PPARγ deficiency andPPARγ agonist improve insulin resistance, which is associated with decreased TG content of muscle/liver and prevention of adipocyte hypertrophy.
616 citations
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TL;DR: This review covers the literature on simple indole alkaloid and those with a nonrearranged monoterpenoid unit and newly isolated alkaloids, structure determinations, total syntheses and biological activities.
531 citations
Authors
Showing all 1322 results
Name | H-index | Papers | Citations |
---|---|---|---|
Grant R. Wilkinson | 82 | 200 | 26940 |
Sei Sasaki | 77 | 380 | 20644 |
Koiti Titani | 73 | 237 | 16927 |
Kazuto Nishio | 71 | 578 | 18190 |
Hiroshi Ito | 70 | 1029 | 25429 |
Mikio Shoji | 64 | 379 | 16174 |
Masahiko Kurabayashi | 61 | 622 | 15991 |
Naoya Fujita | 58 | 146 | 11096 |
Hiroshi Sakagami | 55 | 750 | 21457 |
Tetsu Akiyama | 54 | 188 | 16294 |
Richard Malik | 53 | 377 | 9445 |
Kenichi Ishibashi | 52 | 142 | 7676 |
Takashi Morita | 50 | 169 | 8027 |
Jun-ichi Satoh | 48 | 182 | 5930 |
Takashi Sugita | 44 | 241 | 6688 |