NF-κB in Oxidative Stress.
TLDR
A greater understanding of the complex interplay between the NF-κB signaling and oxidative stress may lead to the development of therapeutic strategies for the treatment of a myriad of human diseases for which oxidative stress has an etiologic role.About:
This article is published in Current Opinion in Toxicology.The article was published on 2017-11-07 and is currently open access. It has received 417 citations till now. The article focuses on the topics: Oxidative stress & Reactive oxygen species.read more
Citations
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ROS in cancer therapy: the bright side of the moon
Bruno Perillo,Marzia Di Donato,Antonio Pezone,Erika Di Zazzo,Pia Giovannelli,Giovanni Galasso,Gabriella Castoria,Antimo Migliaccio +7 more
TL;DR: The review will emphasize the molecular mechanisms useful for the development of therapeutic strategies that are based on modulating ROS levels to treat cancer, and report on the growing data that highlight the role of ROS generated by different metabolic pathways as Trojan horses to eliminate cancer cells.
Journal ArticleDOI
Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
Javier Checa,Josep M Aran +1 more
TL;DR: In-depth knowledge of the molecular mechanisms of ROS actuation and their influence under steady-state and stressful conditions will pave the way for the development of novel therapeutic interventions to mitigate the harmful outcomes of ROS in the onset and progression of a variety of chronic inflammatory and age-related diseases.
Journal ArticleDOI
Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
Burak Ibrahim Arioz,Bora Tastan,Emre Tarakcioglu,Kemal Ugur Tufekci,Melis Olcum,Nevin Ersoy,Alper Bagriyanik,Kursad Genc,Sermin Genc +8 more
TL;DR: Melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition ofNLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1 β (IL-1β) maturation and secretion.
Journal ArticleDOI
Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
TL;DR: The importance of reactive oxygen species (ROS) in regulating cell functioning and communication among themselves and the relevance of ROS in therapy concepts is addressed here.
Journal ArticleDOI
Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy
TL;DR: In this paper, a review highlights the link between disturbed lipid metabolism and oxidative stress in the context of NAFLD and discusses potential therapies based on antioxidant effects and their likely molecular targets.
References
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Journal ArticleDOI
Signaling to NF-kappaB.
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: An overview of established NF-kappaB signaling pathways is provided with focus on the current state of research into the mechanisms that regulate IKK activation and NF- kappaB transcriptional activity.
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
TL;DR: It is shown that micromolar concentrations of H2O2 can induce the expression and replication of HIV‐1 in a human T cell line and suggests that diverse agents thought to activate NF‐kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI.
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Multiple nuclear factors interact with the immunoglobulin enhancer sequences.
Ranjan Sen,David Baltimore +1 more
TL;DR: In this paper, an electrophoretic mobility shift assay with end-labeled DNA fragments was used to characterize proteins that bind to the immunoglobulin (Ig) heavy chain and the kappa light chain enhancers.
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Crosstalk of reactive oxygen species and NF-κB signaling.
Michael J. Morgan,Zheng-gang Liu +1 more
TL;DR: The regulation of ROS levels by NF-κB targets and various ways in which ROS have been proposed to impact NF-σκB signaling pathways are reviewed.
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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
Osman N. Ozes,Lindsey D. Mayo,Jason A. Gustin,Susan R. Pfeffer,Lawrence M. Pfeffer,David B. Donner +5 more
TL;DR: It is shown that the Akt serine–threonine kinase is involved in the activation of NF-κB by tumour necrosis factor (TNF), and that Akt is part of a signalling pathway that is necessary for inducing key immune and inflammatory responses.